Controlled absorption methyldopa pharmaceutical formulation

Details Controlled absorption methyldopa pharmaceutical formulation Controlled absorption methyldopa pharmaceutical formulation

1984-12-20

1987-12-29

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424462, 424468, 424473, 424490, 424497, 514965, A61K 950, A61K 958

Patent

active

047160403

ABSTRACT:
A controlled absorption methyldopa formulation for oral administration comprises a pellet having a core of methyldopa or a pharmaceutically acceptable salt thereof in association with an organic acid, and an outer membrane which permits release of methyldopa in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured in a Basket Assembly according to U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m., is not more than 50% of the total methyldopa after one hour of measurement. Not more than 80% of the total methyldopa is released after a total of 3 hours of measurement and 100% release is achieved after a total of 7 hours.

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