Controlled absorption diltiazen pharmaceutical formulation

Details Controlled absorption diltiazen pharmaceutical formulation Controlled absorption diltiazen pharmaceutical formulation

1984-12-20

1988-01-26

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424462, 424468, 424473, 424490, 424497, 514965, A61K 950, A61K 958

Patent

active

047216190

ABSTRACT:
A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and an outer membrane which permits release of diltiazem in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured according to the Paddle Method of U.S. Pharmacopoeia XX, is not more than 10% of the total diltiazem after 2 hours of measurement in a buffered medium. Not more than 30% of the total diltiazem is released after a total of 4 hours measurement and not more than 40% of the total diltiazem is released after a total of 6 hours. 100% release is achieved after 12 hours, with a maximum of 80% of the total diltiazem being released after 8 hours.

REFERENCES:
patent: 3965255 (1976-06-01), Bloch et al.
patent: 4230687 (1980-10-01), Sair et al.
patent: 4263273 (1981-04-01), Appelgren et al.
patent: 4361546 (1982-11-01), Stricker et al.
patent: 4499066 (1985-02-01), Moro et al.
patent: 4555399 (1985-11-01), Hsiao
patent: 4592753 (1986-06-01), Panoz
patent: 4600645 (1986-07-01), Ghebre-Sellassie et al.
patent: 4609542 (1986-09-01), Panoz et al.
patent: 4610870 (1986-09-01), Jain et al.
Chemical Abstracts, vol. 100, No. 18, Apr. 30, 1984, p. 367.

Affiliated with

Also associated with

Rating

Controlled absorption diltiazen pharmaceutical formulation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled absorption diltiazen pharmaceutical formulation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled absorption diltiazen pharmaceutical formulation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1467486