Controlled absorption diltiazen formulation for once-daily admin

Details Controlled absorption diltiazen formulation for once-daily admin Controlled absorption diltiazen formulation for once-daily admin

1994-11-04

1997-04-01

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424457, 424458, 424459, 424462, 424468, 424490, A61K 916

Patent

active

056163452

ABSTRACT:
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming, water insoluble synthetic polymer and a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer being effective to permit release of the diltiazem from the pellet at a rate allowing controlled absorption thereof over a twenty four hour period following oral administration.

REFERENCES:
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patent: 4443497 (1984-04-01), Samejima
patent: 4459279 (1984-07-01), Strickler
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patent: 4814183 (1989-03-01), Zentner
patent: 4894240 (1990-01-01), Geoghegan
Modern Pharmaceutics (1979) (vol. 6, pp. 138-161), "Sustained and Controlled Release Drug Delivery Systems", edited by Joseph R. Robinson.

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