Controlled absorption diltiazem formulation

Details Controlled absorption diltiazem formulation Controlled absorption diltiazem formulation

1987-11-16

1990-04-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424459, 424462, 424470, 424493, 424494, 424495, 424497, A61K 912, A61K 916, A61K 926

Patent

active

049178997

ABSTRACT:
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and a membrane surrounding the core comprising a multiplicity of sequentially applied and dried layers, each layer containing a major proportion of a pharmaceutically acceptable film-forming, water insoluble, naturally occurring polymer and a minor proportion of a pharmaceutically acceptable film-forming, water soluble polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer being effective to permit release of the diltiazem from the pellet at a rate allowing controlled absorption thereof over a twelve hour period following oral administration.

REFERENCES:
patent: 3965255 (1976-06-01), Bloch et al.
patent: 4230687 (1980-10-01), Sair et al.
patent: 4263273 (1981-04-01), Appelgren et al.
patent: 4361546 (1982-11-01), Stricker et al.
patent: 4432966 (1984-02-01), Zeitoun et al.
patent: 4496558 (1985-01-01), DeMarinis et al.
patent: 4499066 (1985-02-01), Moro et al.
patent: 4555399 (1985-11-01), Hsiao
patent: 4592753 (1986-06-01), Panoz
patent: 4606909 (1986-08-01), Bechgaard et al.
patent: 4609542 (1986-09-01), Panoz et al.
patent: 4610870 (1986-09-01), Jain et al.
patent: 4660645 (1986-07-01), Ghebre-Sellassie et al.
patent: 4666702 (1987-05-01), Junginger
patent: 4684516 (1987-08-01), Bhutani
patent: 4756911 (1988-07-01), Drost et al.
Chemical Abstracts, vol. 100, No. 18, Apr. 30, 1984, p. 367, Abstract 145016c.

Affiliated with

Also associated with

Rating

Controlled absorption diltiazem formulation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled absorption diltiazem formulation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled absorption diltiazem formulation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1051500