Control system for simulated moving bed chromatography

Details Control system for simulated moving bed chromatography Control system for simulated moving bed chromatography

2007-08-30

2010-10-05

Hepperle, Stephen (Department: 3753)

Fluid handling

Systems

Multiple inlet with multiple outlet

C700S282000

Reexamination Certificate

active

07806137

ABSTRACT:
The present invention provides devices and methods for micro-scale simulated moving bed chromatography (SMB) for continuous preparation of analytic quantities of highly pure fractions of target molecules. The present apparatus and method of the invention is adapted in a preferred embodiment to separations by affinity chromatography involving three discontinuous liquid flow loops. An alternative embodiment of affinity chromatography utilizes standard SMB operating under isocratic conditions.

REFERENCES:
patent: 4703913 (1987-11-01), Hunkapiller
patent: 5203368 (1993-04-01), Barstow et al.
patent: 5775371 (1998-07-01), Pan et al.
patent: 6102068 (2000-08-01), Higdon et al.
patent: 6544413 (2003-04-01), Nagamatsu et al.

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