Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-02-01
1996-10-29
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514356, 514211, 514171, 514174, 5142258, 514648, 424646, A61K 31135, A61K 3144, A61K 3155, A61K 3156, A61K 3158, A61K 3154, A61K 3324
Patent
active
055696783
ABSTRACT:
This invention pertains to a method for controlling wound scar production by administering a calcium antagonist, alone or in a combination with or followed by a steroid, to the wound site. The method can be used to minimize wound scars, such as hypertrophic wound healing disorders, keloids and burn scar contractures in humans or other mammals, particularly those individually prone to excesssive scarring.
REFERENCES:
patent: 4806464 (1989-02-01), Spelsberg
patent: 5132119 (1992-07-01), Lee
Van Bockxmeer, F. M., et al., "Models for Assessing Scar Tissue Inhibitors," Retina, 5(1):47-60 (1985).
Lotfi, A. M., et al., "Mesenteric fibromatosis complicating familial adenomatous polyposis: predisposing factors and results of treatment," Int. J. Colorectal Dis., 4(1):30-36 (1989).
Massoud, E., "Traitement des ch eloides et des cicatrices hypertrophiques par la triamcinolone ac etonide," Ann. Chir. Plast., 15(1):54-56 (1970).
Berkow, R., et al., "The Merck Manual of Diagnosis and Therapy," Merck Sharp & Dohme Research Laboratories, Rahway, NJ, p. 2306 (1987).
Lipton, A., et. al., "Calcium antagonism by the antioestrogen tamoxifen," Cancer Chemother. Pharmacol., 18(1):17-20 (1986).
McGonigal, M. D., et al., "The effects of breast cancer chemotherapy on wound healing in the rat," J. Surg. Res., 42(5):560-564 (1987).
Smedley, M. and Stanisstreet, M., "Effect of calmodulin inhibitors on wound healing in Xenopus early embryos," Cytobios 42:25-32. (1985).
Cohen, I. K. and Keiser, H. R., "Collagen synthesis in keloid and hypertrophic scar following intralesional use of Triamcinolone," Surg. Forum 24:521-3 (1973).
Salmela, K., "Comparison of the effects of methylprednisolone and hydrocortisone on granulation tissue development," Scand. J. Plast. Reconst. Surg. 15:87-91 (1981).
Askey, D. B. et al., J. Cell Biol., Joint Meeting of American Society for Cell Biol. and American Society for Biochem. and Mol. Bio., San Francisco, CA, abt. #1905, p. 336a, Jan. 29-Feb. 2, 1989.
Askey, D. B. et al., Proceedings Electrochemical Society, Los Angeles, CA, May 7-12, 1989.
Ohmori, S., Aesthetic Plastic Surgery 12:95-99 (1988).
Chen, C. et al., Science 239:1024-1026 (1988).
Onuma, E. K. and S.-W. Hui, J. Cell Bio. 106:2069-2075 (1988).
McLeod, K. J. et al., Science 236:1465-1469 (1987).
Abergel, R. P. et al., J. Invest. Dermatol. 84:384-390 (1985).
Miller, E. A., "Electric Field Modulation of Exocytosis in Human Fibroblasts", S. B. Thesis, M.I.T. 1987, pp. 16-17 and 49-50.
Sank, A. et al., Surgery 106:1141-1148 (Dec. 1989).
Steinleitner, A. et al., J. Reproductive Medicine, 33:891-894 (Nov. 1988).
Block, L. H. et al., Proc. Natl. Acad. Sci. USA 86:2388-2392 (Apr. 1989).
Lee, R. C. and J. Ping, J. Surg. Res. 49:463-466 (1990).
McLeod, K. J., "Modulation of Biosynthesis by Physiologically Relevant Electric Fields", Ph.D. Thesis, Massachusettes Institute of Tehnology, 1986.
Aggeler, J., Cell motility and the Cytoskeleton 16:121-132 (1990).
Clark, C. P. et al., Surgery 109:502-506 (Apr. 1991).
Kinzbruner, Cancer 52:2201-2204 (1983).
Unemori, J. Cell Bio 103:1021-1031 (1986).
Smedley et al., Chem. Abstracts CA102(21):183051j, 1985.
Salmela, Chem. Abstracts CA96(11):80194m, 1981.
Cohen et al., Chem. Abstracts CA81(1):270k, 1973.
Lossnitzer et al, Chemical Abstracts, vol. 97, No.25, 1982, p. 59, abstract No. 207995b.
Arch Develop.
Cintins Marianne M.
Jarvis William R. A.
Massachusetts Institute of Technology
LandOfFree
Control of wound scar production does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Control of wound scar production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Control of wound scar production will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1785942