Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-10-25
2005-10-25
Leffers, Gerry (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S069100, C435S419000, C800S278000, C530S350000
Reexamination Certificate
active
06958236
ABSTRACT:
Chimeric insect hormone receptors and receptor cassettes are provided as well as methods for their use in regulating expression of target polypeptides in plants in the presence of appropriate chemical ligands. In particular, each receptor cassette encodes a receptor polypeptide that comprises a DNA binding domain, a hinge region, a ligand binding domain and an activation domain. According to one embodiment, the hinge and ligand binding domains are from two different insect ecdysone receptors. According to another embodiment, the receptor cassettes are chimeric in that one or more of the DNA binding or activation domains are obtained from a source heterologous with respect to the other domains present in the chimeric receptor cassette.
REFERENCES:
patent: 4833080 (1989-05-01), Brent et al.
patent: 4981784 (1991-01-01), Evans et al.
patent: 5171671 (1992-12-01), Evans et al.
patent: 5262300 (1993-11-01), Evans et al.
patent: 5534418 (1996-07-01), Evans et al.
patent: 5614395 (1997-03-01), Ryals et al.
patent: 5641652 (1997-06-01), Oro et al.
patent: 5688691 (1997-11-01), Oro et al.
patent: 5707800 (1998-01-01), Mangelsdorf et al.
patent: 5710004 (1998-01-01), Evans et al.
patent: 5874534 (1999-02-01), Vegeto et al.
patent: 5880333 (1999-03-01), Goff et al.
patent: 6379945 (2002-04-01), Jepson et al.
patent: 6504082 (2003-01-01), Albertsen et al.
patent: 2002/0119521 (2002-08-01), Palli et al.
patent: 0 332 104 (1989-06-01), None
patent: WO 90 11273 (1990-10-01), None
patent: WO 91 13167 (1991-09-01), None
patent: WO 91 14695 (1991-10-01), None
patent: WO 93 03162 (1993-02-01), None
patent: WO 93 06215 (1993-04-01), None
patent: WO 93 21334 (1993-10-01), None
patent: WO 93 23431 (1993-11-01), None
patent: WO 91 12258 (1994-01-01), None
patent: WO 94 01558 (1994-01-01), None
patent: WO 96 27673 (1996-09-01), None
patent: WO 96 37609 (1996-11-01), None
patent: WO 97 38117 (1997-10-01), None
patent: WO 99 02683 (1999-01-01), None
Martinez et al,Creation of ecdysone receptor chimeras in plants for controlled regulation of gene expression Molecular&General Genetics, vol. 261 (1999), pp. 546-552.
Wang et al,Molecular Deteriminants of Differential Ligand Sensitivities of Insect Ecdysteroid Receptors Molecular and Celluar Biology, vol. 20, No. 11 (Jun. 2000), pp. 3870-3879.
Beato, M.,Gene Regulation by Steroid, Cell, vol. 56 (Feb. 10, 1989) pp. 335-344.
Brent, R. and Ptashne, M.,A Eukaryotic Transcriptional Activator Bearing the DNA Specificity of a Prokaryotic Repressor Cell, vol. 43 (1985) pp. 729-736.
Christianson, A. and Kafatos, F.,Binding Affinity of the Drosophila melanogaster CF1/USP Protein to the Chorion s15 Promoter Biochemical and Biophysical Research Communications, vol. 193, No. 3 (Jun. 30, 1993) pp. 1318-1323.
Christopherson, et al.,Ecdysteroid-dependent regulation of genes in mammalian cells by a Drosophila ecdysone receptor and chimeric transactivators, Proceedings of the National Acedmy of Sciences, vol. 89 (1992) pp. 6314-6318.
Desjarlais, J. R. and Berg, J. M.,Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins Proceedings of the National Academy of Science, USA, vol. 90 (Mar. 1993), pp. 2256-2260.
Dhadialla et al.,New Insecticides with Ecdysteroidal and Juvenile Hormone Activity Annual Review of Entomology, vol. 43 (1998) pp. 545-569.
Evans, R.,The Steriod and Thyroid Hormone Receptor Superfamily Science, vol. 240 (May 13, 1988) pp. 889-895.
Fujiwara et al.,Cloning of an Ecdysone Receptor Homolog from Manduca Sexta and the Development Profile of its mRNA in Wings Insect Biochemistry and Molecular Biology, vol. 25, No. 7 (1995) pp. 845-856.
Gaffney et al.,Requirement of Salicyliuc Acid for the Induction of Systemic Acquired Resistance Science, vol. 261 (Aug. 6, 1993) pp. 754-756.
Goff, et al.,Identification of functional domains in the maize transcriptional activator C1: comparison of wild-type and dominant inhibitor proteins Genes&Development, vol. 5 (1991) 298-309.
Harmon et al.,Activation of mammalian retinoid X receptors by the insert growth receptor methoprene Proceedings of the National Academy of Sciences, vol. 92 (Jun. 1995) p. 6157-6160.
Henrich, et al.,A steriod/thyroid hormone receptor superfamily member in Drosophila melanogaster that shares extensive sequence similarity with a mammalian homologue Nucleic Acids Research, vol. 18, No. 14 (1990) pp. 4143-4148.
Jones, G. and Sharp, Phillip,Ultraspiracle: An invertebrate nuclear receptor for juvenile hormones Proceeedings of the National Academy of Sciences, vol. 94 (Dec. 1997), pp. 13499-13503.
Koelle, et al.,The Drosophila EcR Gene Encodes an Ecdysone Receptor, a New Memeber of the Steroid Receptor Superfamily Cell, vol. 67 (1991) pp. 59-77.
Kothapalli, et al., Cloning and development expression of the ecdysone receptor gene from th spruce budworm,Choristoneura fumiferana Development Genetics, vol. 17 (1995) pp. 319-330.
Liu, et al.,Design of polydactyl zinc-finger proteins for unique addressing within complex genomes Proceedings of the National Academy of Science, USA, vol. 94 (May 1997) pp. 5525-5530.
Llyod et al.,Epidermal Cell Fate Determination in Arabidopsis: Patterns Defined by a Steroid-Inducible Regulator Science, vol. 266 (Oct. 21, 1994) pp. 436-439.
Martinez et al.,A chemically inducible gene expression system for plants based on the ecdysteroid receptor from Heliothis virescens Plant Physiology, (Supp.) vol. 114, No. 3 (Jul. 1997), pp. 258.
Meijer, et al.HD-Zip proteins of families I and II from rice: interactions and functional properties Molecular and General Genetics, vol. 263 (2000) pp. 12-21.
Meshi, T. and Iwabuchi M.,Plant Transcription Factors Plant Cell Physiology, vol. 36(8) (1995) pp. 1405-1420.
Ng, H. and Bird, A.,Histone deacetylases: silencers for hire Trends in Biochemical Sciences, vol.25 (Mar. 2000) pp. 121-126.
Oro, et al.,Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor Nature, vol. 347 (Sep. 20, 1990), pp. 298-301.
Oro, et al.,The Drosophila nuclear receptors: new insight into the actions of nuclear receptors in development Current Opinion in Genetics and Development, vol. 2 (1992), pp. 269-274.
Palli, et al.,A nuclear juvenile hormone-binding protein from larvae of Manduca Sexta: A putative receptor for the metamorphic action of juvenile hormone Proceedings of the National Academy of Sciences, vol. 91 (Jun. 1994), pp. 6191-6195.
Parker et al.,Structure and function of nuclear hormone receptors Seminars in Cancer Biology, vol. 1 (1990) p. 81-87.
Picard et al., A Movable and Regulable Inactivation Function within the Steroid Binding Domain of the Glucocorticoid ReceptorCell, vol. 54 (Sep. 23, 1988) pp. 1073-1080.
Ptashne M.,How eukaryotic transcriptional activators work Nature, vol. 335 (1988) pp. 683-689.
Riddiford, L.,Hormone Receptors and the Regulation of Insect Metamorphosis Receptor, vol. 3 (1993) pp. 203-209.
Sadowski, et al.,GAL4-VP16 is an unusually potent transcriptional activator Nature, vol. 335 (1988) 563-564.
Saleh, D., et al.,Cloning and characterization of an ecdysone receptor cDNA from Locus migratoria Molecular And Cellular. Endocrinology, vol. 143 (1998) pp. 91-99.
Schene, M., et al.,A steroid-inducible gene expression system for plant cells Proceedings of the National Academy of Sciences, vol. 88 (Dec. 1991) pp. 10421-10425.
Segraves, A.,Something Old, Some Things New: The Steriod Receptor Superfamily in Drosophila Cell, vol. 67 (Oct. 18, 1991) pp. 225-228.
Sutherland, et al.,Drosophila hormone receptor 38: A second partner for Drosophila USP suggests an unexpected role for nuclear receptors of the nerve growth factor-induced protein B type Proceedings of the National Academy of Sciences, vol. 92 (Aug. 1995) pp. 7966-7970.
Swevers et al.,The Silkmoth Homolog of the Drosophila Ecdysone Receptor(B1 Isoform): Cloning and Analysis of Expression During Follicullar Cell Differentiation Insect Biochemistry and Molecular Biology, vol. 25, No. 7 (1995) pp. 857-866.
Thomas, et al.,Heterodimerization of the Drosophila ecdysone receptor with
Brown Jeffrey A.
Cockrell Adam S.
Johnson Brian D.
Pascal Erica J.
Valentine Scott A.
Kakefuda Mary
Leffers Gerry
Marvich Maria
Syngenta Participations (AG)
LandOfFree
Control of gene expression in plants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Control of gene expression in plants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Control of gene expression in plants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3489333