Control of gene expression in eukaryotic cells

Chemistry: molecular biology and microbiology – Plant cell or cell line – per se ; composition thereof;... – Plant cell or cell line – per se – contains exogenous or...

Reexamination Certificate

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C800S295000, C800S303000

Reexamination Certificate

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11145451

ABSTRACT:
DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.

REFERENCES:
patent: 6265638 (2001-07-01), Bidney et al.
patent: 6943243 (2005-09-01), Oulmassov et al.

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