Control of gene expression in eukaryotic cells

Details Control of gene expression in eukaryotic cells Control of gene expression in eukaryotic cells

2005-09-13

2005-09-13

McKelvey, Terry (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024100, C435S419000, C435S254200, C800S295000

Reexamination Certificate

active

06943243

ABSTRACT:
DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.

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