Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-07
1998-10-06
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424 9321, 4351721, 4351723, 435375, 604 20, 935 36, 935 62, A61K 4800, A01N 6300, C12N 500, C12N 1500
Patent
active
058176365
ABSTRACT:
This invention relates to genetic constructs which comprise an enhancer-promoter region which is responsive to radiation, and at least one structural gene whose expression is controlled by the enhancer-promoter. This invention also relates to methods of destroying, altering, or inactivating cells in target tissue by delivering the genetic constructs to the cells of the tissues and inducing expression of the structural gene or genes in the construct by exposing the tissues to ionizing radiation. This invention is useful for treating patients with cancer, clotting disorders, myocardial infarction, and other diseases for which target tissues can be identified and for which gene expression of the construct within the target tissues can alleviate the disease or disorder.
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Hallahan Dennis E.
Kufe Donald W.
Sukhatme Vikas P.
Weichselbaum Ralph R.
Arch Development Corp.
Campell Bruce R.
Dana-Farber Cancer Institute
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