Control of drug release by transient modification of local...

Details Control of drug release by transient modification of local... Control of drug release by transient modification of local...

2006-01-25

2009-02-10

Monshipouri, Maryam (Department: 1656)

Surgery

Controlled release therapeutic device or system

C424S426000, C514S012200, C228S124600

Reexamination Certificate

active

07488316

ABSTRACT:
Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device. The drug formulation and the release-modifying agent may be stored together in at least one reservoir in the implantable drug deliver device. Alternatively, the release-modifying agent may be stored in one or more reservoirs separate from the drug formulation.

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