Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-03-27
2000-10-24
Ungar, Susan
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530302, A61K 3800
Patent
active
06136780&
ABSTRACT:
The present invention is related to the treatment and prevention of cancer including particularly gastrointestinal cancer. More specifically, the present invention describes the use of naltrexone, naloxone and the pentapeptide growth factor [Met.sup.5 ]-enkephalin to inhibit and arrest the growth of cancer. Such efficiency has been discovered to be a consequence of the functional manipulation of the zeta (.zeta.) opioid receptor through endogenous [Met.sup.5 ]-enkephalin. This receptor has been determined to be present in growing cancers such as pancreatic and colon cancer, for example.
REFERENCES:
patent: 4801614 (1989-01-01), Plotnikoff
patent: 5266574 (1993-11-01), Zagon et al.
Zagon et al, Gastro enterology 102: A299, 1992.
Zagon et al Brain Res, 630:295-302, 1993.
Zagon IS et al. Brain Res. 480(1-2):16-28, 1989.
Zagon IS et al. Life Sci. 43:1313-1318, 1988.
KiKuchi, Y et al. Gynecol. Oncol. 32(1):60-4, 1989.
Bosturck, DG. et al. N. Engl. J. Med. 317(23):1439-43, 1987.
Porto, DP. et al. Am. J. Otolaryngol 8(2):97-104, 1987.
D'Amore, ESG. et al. Human Pathol. 22(3):276-286, 1991.
Minn, AJ. et al. Blood, 86(5):1903-1910, 1995.
Osband, ME. et al. Immunol. Today 11:193-195, 1990.
McLauglin, PJ. et al. Gastroenterology, 108 (4 Suppl.) A505, 1995.
Murgo, AJ. et al. JMCI 75(2):341-344, 1985.
Behr et al., (1997), "Radioimmunotherapy of Solid Tumors: A Review `Of Mice and Men`." Hybridoma, vol. 16, No. 1, pp. 101-107.
Bodey et al., (1996), "Human Cancer Detection And Immunotherapy With Conjugated and Non-Conjugated Monoclonal Antibodies." Anticancer Research, 16:661-674.
Clarke et al., (1996), "Human Breast Cancer Cell Line Xenografts As Models Of Breast Cancer- The Immunobiologies Of Recipient Mice And The Characteristics Of Several Tumorigenic Cell Lines." Breast Cancer Research And Treatment, 39:69-86.
Hytrek et al., (Oct. 1994), "Endogenous Opioid Systems And Human Colon Carcinomas Grown in Nude Mice.", Lab Animal Sci., 33:A-16.
Hytrek et al., (1995), Characterization of the Zeta (.zeta.) Opioid Receptor in Human Colon Cancer., FASEB J., 9:A703.
Hytrek et al., (May 1995), "Opioid Groth Factor Modulates Tumorigenesis Of Human Colon Carcinomas Grown In Nude Mice." Gastroenterology, 108: A483.
Hytrek et al., (1996), "Identification And Characterization of .zeta.-Opioid Receptor In Human Colon Cancer." Amer. J. Physiol., 271 (1 part 2) R115-R121.
Hytrek et al., (1996), "Inhibition Of Human Colon Cancer By Intermittent Opioid Receptor Blockade With Naltrexone." Cancer Letters 101, pp. 159-164.
Hytrek et al., (1996), "Inhibition Of Human Colon Cancer By Naltrexone.", Gastroenterology, 110:A532.
Hytrek et al., "Presence of Opioid Growth Factor (OGF) And Zeta (.zeta.) Opioid Receptor, and the Autocrine Production of OGF, in human colon cancer cells in vitro." FASEB J., 10:A181.
Royai et al., (Dec. 1996) "Preclinical Models Of Prostate Cancer." Seminars in Omcology, vol. 23, No. 6, Suppl. 14, pp. 35-40.
Wenisch, H.J.C., (1996), "Xenotransplantation of Human Thyroid Carcinomas In Athymic Nude Mice." Exp. Clin. Endocrinol Diabetes, 104, Suppl. 3, pp. 61-63.
Zagon et al., (Nov. 1987) "Opioid Receptors And Endogenous Opioids In Diverse Human And Animal Cancers." JNCI, vol. 79, No. 5, pp. 1059-1065.
Zagon et al., (1995), "Opioid Growth Factor Modulates Corneal Epithelial Outgrowth In Tissue Culture." Amer. Phys. Soc., vol. 268 (4 pt 2 pp. R942-R950.
Zagon et al., (1996), "Opioid Growth Factor ([Met5]Enkephalin) Prevents The Incidence And Retards The Growth Of Human Colon Cancer." Amer. J. Physiol., vol. 271 (3 pt 2) pp. R780-R786.
Zagon et al., (1997), "Opioid Growth Factor (OGF) Inhibits Human Pancreatic Cancer Transplanted Into Nude Mice." Cancer Letters 112, pp. 167-175.
Zagon, et al., (May 1995), "Presence of OGF and Zeta (.zeta.) Opioid Receptor In HT-29 Human Colon Cancer." Gastroenterology, 108: A402.
Zagon et al., (1995), "OGF and the .zeta. Opioid Receptor Are Present And Function In Human And Mouse Epidermis.", Mol. Biol. Cell 6, (Suppl.) 235a, Abstract No. 1362.
Zagon et al., (1996), "Opioid Growth Factor Inhibits The Growth of HT-29 Human Colon Cancer Cells In Vitro." FASEB J., 10:A181e.
Aylsworth et al. (1979) "Opiate Antagonists Can Inhibit Mammary Tumor Growth in Rats" Proceedings of the Society for Experimental Biology and Medicine 161:18-20.
Faith et al. (1988) "Inhibition of Pulmonary Metastases and Enhancement of Natural Killer Cell Activity by Methionine-Enkephalin" Brain, Behavior and Immunity 2:114-122.
Horn et al. (1989) "Lack of Effect of the Opioid Antagonist, Naltrexone, on the In Situ Growth of C-1300, NIE-115 and NS206 Murine Neuroblastoma Tumor Cell Lines" Life Sciences 45:2539-2545.
Iishi et al. (1991) "Enhancement by Methionine Enkephalin of Colon Carcinogenesis Induced by Azoxymethane" Cancer Research 51:785-788.
Kikuchi et al. (1987) "Effects of Naloxone on Human Ovarian Cancer Cell Growth in Vitro and in Vivo" Jpn. J. Cancer Res. 78:519-525.
Koo et al. (1996) "Relative Efficacy of the Opioid Antagonist, Naltrexone, on the Initiation and Promotion Phases of Rat Mammary Carcinogenesis" Anticancer Research 16:1893-1898.
Lee et al. (1994) "Differential effects of Methionine Enkephalin on the Growth of Brain Tumor Cells" Journal of Neuro-Oncology 19:11-15.
Lewis et al. (1983) "Apparent Involvement of Opioid Peptides in Stress-Induced Enhancement of Tumor Growth" Peptides 4:635-638.
Lissoni et al. (1993) "Radioendocrine Therapy of Brain Tumors with the Long Acting Opioid Antagonist Naltrexone in Association with Radiotherapy" Ovid Citation 281 [http://ovid.hslc.org] abstract of Tumori 79(3):198-201.
Maneckjee et al. (1990) "Opioid and Nicotine Receptors Affect Growth Regulation of Human Lung Cancer Cell Lines" Proc. Natl. Acad. Sci. USA 87:3294-3298.
Mascarenhas et al. (1992) "Inhibitory Effect of Tumor Growth by Methionine-enkephalin" (translated from Portuguese) Ovid Citation 83 [http://ovid.hslc.org] abstract of Arquivos de Neuro-Psiquiatria 50(1):84-90.
Murgo, A. (1986) "Effects of [Met]Enkephalin and Corticosterone on Thymus Weight and Tumor Growth" Neuroendocrinol. Lett. 8:79-85.
Murgo, A. (1989) "Modulation of Murine Melanoma Growth by Naloxone" Cancer Letters 44:137-142.
Scholar et al. (1987) "The Antimetastatic Activity of Enkephalin-Like Peptides" Cancer Letters 35:133-138.
Shavit et al. (1983) "Endogenous Opioids may Mediate the Effects of Stress on Tumor Growth and Immune Function" Proc. West. Pharmacol. Soc. 26:53-56.
Simon et al. (1984) ".beta.-Endorphin Injected into the Nucleus of the Raphe Magnus Facilitates Metastatic Tumor Growth" Brain Research Bulletin 12:487-491.
Tejwani et al. (1989) "Naltrexone Inhibits Rat Mammary Tumorigenesis Induced by Stress and a Carcinogen" Advances in the Bioscience 75:615-618.
Zagon et al. (1989) "Characterization of Zeta (.zeta.):A New Opioid Receptor Involved in Growth" Brain Research 482:297-305.
Zagon et al. (1990) "Demonstration and Characterization of Zeta (.zeta.), a Growth-related Opioid Receptor, in a Neuroblastoma Cell Line" Brain Research 511:181-186.
Zagon et al. (1991) "Zeta (.zeta.), a Growth-related Opioid Receptor in Developing Rat Cerebellum: Identification and Characterization" Brain Research 551:28-35.
Zagon et al. (1993) "Zeta (.zeta.), the Opioid Growth Factor Receptor: Identification and Characterization of Binding Subunits" Brain Research 605:50-56.
McLaughlin Patricia J.
Zagon Ian S.
Davis Minh Tam
Monahan Thomas J.
The Penn State Research Foundation
Ungar Susan
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