Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1997-11-03
1999-11-16
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 932, 424 935, 424 93, 424 9361, A61B 5055
Patent
active
059852453
ABSTRACT:
There is provided a contrast medium composition comprising: (a) a first contrast agent comprising a physiologically tolerable manganese compound, a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group, or salt thereof, having a manganese concentration of at least 0.3 mM or being in a dosage unit form containing at least 300 .mu.mol manganese, together with (b) a second contrast agent. Such compositions have been found to be particularly suited to imaging of the liver.
REFERENCES:
patent: 5128121 (1992-07-01), Berg et al.
patent: 5143716 (1992-09-01), Unger
patent: 5292729 (1994-03-01), Ashmead
patent: 5314681 (1994-05-01), Leunbach et al.
Formulation of Radiographically Detectable Gastrointestinal Contrast Agents for Magnetic Resonance Imaging: Effects of a Barium Sulfate Additive on MR Contrast Agent Effectiveness, Rubin et al., Magnetic Resonance in Medicine 23, 154-165 (1992).
Chromium and Chronic Ascorbic Acid Depletion Effects on Tissue Ascorbate, Manganese, and .sup.14 C Retention from .sup.14 C-Ascorbate in Guinea Pigs, Seaborn et al., Biological Trace Element Research, vol. 41, 1994.
Effects of Copper, Iron, and Ascorbic Acid on Manganese Availability to Rats, P.E. Johnson, et al., P.S.E.B.M, vol. 199, 470-480, 1992.
Efectele Tratamentului Acut Cu Mangan Asupra Unor Parametri Biochimici La Puii De Gaina, R. Giurgea et al., Studii si cercetari de Biologie seria biologie animala, Decembre 1992.
Trace Element Absorption in Infants as a Foundation to Setting Upper Limits for Trace Elements in Infant Formulas.sup.1, Bo Lonnerdal, The Journal of Nutrition, vol. 119, No. 12S, 1988.
Higher Retention of Manganese in Suckling Than in Adult Rats is Not Due to Maturational Differences in Manganese Uptake by Rat Small Intestine, Janet G. Bell et al., Journal of toxicology and Environmental Health, vol. 26, No. 4, 1989.
Stability of Yttrium (III) Complexes of Substituted 3-Hydroxy-4H-Pyran-4-ones in Aqueous Solution, R. Petrola, Finnish Chemical Letters, vol. 13, No. 5, pp. 129-135, 1986.
Thermodynamics of Kojate Complexes of the Lanthanides, R. Stampfli et al., Journal of Coordination Chemistry, vol. 1, No. 3, pp. 173-178, Feb. 1972.
Stabilites thermodynamiques des complexes de l'acide kojique, un a-cetoenol, avec des cations divalents: Mn, Co, Ni, Cu et Zn, C. Gerard et al., Bull. Soc. Chim. Fr., No. 11-12, Pt. 1, pp. 2404-2408, 1975.
Sommaire de la Premiere Partie Chimie Analytique, Minerale et Physicochimie, Bull. Soc. Chim. Fr., No. 11-12, Pt. 1, pp. 451-456, 1979.
Berg Arne
Golman Klaes
Klaveness Jo
Leander Peter
Leunbach Ib
Dees Jos,e G.
Hartley Michael G.
Nycomed Imaging AS
LandOfFree
Contrast agents for MRI using a manganese compound and kojic aci does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Contrast agents for MRI using a manganese compound and kojic aci, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Contrast agents for MRI using a manganese compound and kojic aci will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1320513