Contrast agents for magnetic resonance imaging of the small inte

Details Contrast agents for magnetic resonance imaging of the small inte Contrast agents for magnetic resonance imaging of the small inte

1993-09-17

1995-01-17

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

514492, 514502, 514836, 534 16, 556 1, 556 50, 556 63, 556107, 556134, 556148, 436173, 1286534, A61B 5055, A61K 31295

Patent

active

053824210

ABSTRACT:
A method is provided utilizing contrast agents which provide increased diagnostic information in the magnetic resonance image of the hepatobiliary system and alimentary tract, especially the small intestine. Novel contrast agents which are N-carboxylated desferrioxamine B complexes with metal ions are provided.

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von Bickel, H., "Stoffwechselprodukte von mikroorganismen" Helvetica Chimica Acta (1963) XLVI:1385-1389.
Adapa, S., et al., "Metabolites of microorganisms. Isolation, structure, and synthesis of ferrioxamine H" Helvetica Chimica Acta (1982) 65(179):1818-1824. An English summary is provided.
Herscheid, J. D. M., et al., "N Succinyldesferrioxamine B a potential radiopharmaceutical for assessing renal function" Eur. J. Nucl. Med. (1984) 9(11):508-510. An abstract is enclosed.
Schmeidl, V., et al., "Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: An experimental study in rats" AJR (1986) 147:1263-1270.

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