Contrast agents for image enhancement in magnetic resonance imag

Details Contrast agents for image enhancement in magnetic resonance imag Contrast agents for image enhancement in magnetic resonance imag

1999-01-11

2000-11-14

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 9361, 514182, 514502, 514836, 544 64, 544 78, 548402, 548523, 556138, 556139, 564 82, A61B 5055

Patent

active

061466158

ABSTRACT:
A compound of formula (I): ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R.sup.1, R.sup.2 and R.sup.3, R.sup.4 are ring residues. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue, and a method of administering the second sphere contrast agent.

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