Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1999-04-28
2000-04-18
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
424 95, 424 93, 424 111, 424 165, 548240, A61K 4900, G01N 3100, G01N 3348
Patent
active
060512075
ABSTRACT:
The invention provides a composition of matter of the formula (I): V-L-R where V is a non-peptidic organic group having binding affinity for an endothelin receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body. This composition of matter may be used to image diseases and disorders, particularly of the cardiovascular system.
REFERENCES:
Chan et al., Biochem. Biophys. Res. Commun., 201(1) 228-34 (1994).
Chemical Abstracts, vol. 125, No. 7 (1996), abstract No. 76278.
Database Medline, US National Library of Medicine (NLM), Bethesda, MD, US, AN=97073545.
Cuthbertson Alan
Klaveness Jo
Naevestad Anne
Solbakken Magne
Dees Jos,e G.
Jones Dameron
Nycomed Imaging AS
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