Contrast agents

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Reexamination Certificate

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Details

C424S001110, C424S001650, C424S009300, C424S009500, C544S224000

Reexamination Certificate

active

11108598

ABSTRACT:
The invention provides a composition of matter of formula Iin-line-formulae description="In-line Formulae" end="lead"?V-L-R   (I)in-line-formulae description="In-line Formulae" end="tail"?where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (eg125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.

REFERENCES:
patent: 6264914 (2001-07-01), Klaveness et al.
patent: 6524552 (2003-02-01), Klaveness et al.
patent: 6921525 (2005-07-01), Klaveness et al.

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