Contrast agents

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

Reexamination Certificate

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Details

C424S001110, C424S009100, C424S009200, C424S009300, C424S009500, C548S100000

Reexamination Certificate

active

06921525

ABSTRACT:
The invention provides a composition of matter of the formula (I): V-L-R where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (e.g.125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.

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Model Reactions Targeted at the Synthesis of Carbon 14 Labeled CI-996, a Potent Antagonist of Angiotensin II Receptor (1); Journal of Labelled Compounds and Radiopharmaceuticals, vol.;. XXXIV., No. 3, pp. 213-220, CCC 0362-4803/94/030213-08, 1994 by John Wiley & Sons, Ltd.
Model Reactions Targeted at the Synthesis of Carbon 14 Labeled CI-996, a Potent Antagonist of angiotensin II Receptor (1); Journal of Labelled Compounds and Radiopharmaceuticals , vol. XXXIV., No. 3, pp. 213-220, CCC 0362-4803/94/030213-08, 1994 by John Wiley & Sons, Ltd.

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