Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
1999-06-28
2001-01-16
Walberg, Teresa (Department: 3742)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S473000
Reexamination Certificate
active
06175759
ABSTRACT:
BACKGROUND OF THE INVENTION
The present invention relates generally to infrared spectroscopy and, more specifically, the invention pertains to a Contrast Agent for multispectral infrared transillumination and fluorescence of turbid media.
This invention is for non-invasive multispectral IR absorption and fluorescence measurement system for the detection of blood related abnormalities in tissue. An FDA-approved contrast agent, tailored to the measured spectral range, is introduced intravenously to provide both absorption and fluorescent contrast in tissue. While the full scope of eventual uses will emerge through clinical experience, two immediate areas of application are for the detection of breast cancer and internal bleeding.
SUMMARY OF THE INVENTION
The present invention includes a non-invasive multispectral energy system made up of a transilluminating radiating means that illuminates soft tissues that have been treated with a contrast agent using first and second non-IR illuminating signals to produce thereby a first and second near-IR multispectral images; a means for optically combining the first and second near-IR multispectral images into a combined tissue image; and a means for processing the combined tissue image to detect cancer and tumors.
The non-invasive multispectral imaging system uses a diode laser system that emits the first and second near-IR illuminating signals with wavelengths selected from a range between 750 nm and 1,000 nm as a radiating means and a CCD camera, which is placed in a location with the soft tissues between the CCD camera and the transilluminating radiating means.
To function IR dyes and endogenous chromophores and fluorsphores enhance IR contrast and tumor sites. Intravenous IR contrast agents such as Indocyanine Green (ICG) are used.
It is an object of the invention to provide a system for early detection of breast cancer and internal bleeding. It is another object of the invention to provide a non-invasive multispectral IR tissue imagery system.
These and many other objects and advantages of the present invention will be readily apparent to one skilled in the pertinent art from the following detailed description of a preferred embodiment of the invention and related drawings.
REFERENCES:
patent: 5694938 (1997-12-01), Feng et al.
patent: 5803582 (1998-09-01), Stapleton et al.
patent: 5931789 (1999-08-01), Alfano
patent: 6009340 (1999-12-01), Hsia
Chan Robert W.
Levine Robert Y.
Auton William G.
The United States of America as represented by the Secretary of
Van Quang
Walberg Teresa
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