Contraceptives based on SP22 and SP22 antibodies

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...

Reexamination Certificate

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C424S141100, C424S152100, C424S811000, C530S387900, C530S388200

Reexamination Certificate

active

10897387

ABSTRACT:
Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics are provided.

REFERENCES:
patent: 6197940 (2001-03-01), Klinefelter
patent: 2002/0052011 (2002-05-01), Klinefelter
patent: WO/9727218 (1997-07-01), None
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American Heritage Dictinary definition of reducing downloaded Aug. 29, 2006 from dictionary.reference.com, 2 pages.
Merriam-Websetr OnLine definition of fertle downloaded Aug. 29, 2006 from m-w.com, 3 pages.
Merriam-Websetr OnLine definition of fertlity downloaded Aug. 29, 2006 from m-w.com, 2 pages.
Gilbert, S.F. Developmental Biology, 4thedition, 1994, Sinauer Associates, Inc., pp. 4 and 5.
Brooks, D.E., “Characterization of a 22 kDa Protein with Widespread Tissue Distribution but which is Uniquely Present in Secretions of the Testis and Epididymis and on the Surface of Spermatozoa,” Biochimia et Biophycia Acta, 841:59-70 (1985).
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Welsch, J.E., “A 22 kDa Sperm Protein (SP22) Correlated with Rat Fertility Exhibits Homology with the J-1/thiJ Family of Proteins,”0 Molecular Biology of the Cell, 8:325a (1997).
Yee et al., Contraceptive Vaccines with Sperm Proteins, 693-712 (1995).
Kaydos et al., “Haloacid Induced Alterations in Fertility and the Sperm Biomarker SP22 in the Rat are Additive: Validation of an ELISA,” Toxicological Sciences 81:430-442 (2004).
Klinefelter et al., “Bromochloroacetic Acid Exerts Qualitative Effects on Rat Sperm: Implications for a Novel Biomarker,” Toxicological Sciences 68:164-173 (2002).
Klinefelter et al., “Localization of the Sperm Protein SP22 and Inhibition of Fertility In Vivo and In Vitro,” Journal of Andrology, 23(1):48-63 (2002).
Linder et al., “Dibromoacetic Acid Affects Reproductive Competence and Sperm Quality in the Male Rat,” Fundam Appl Toxicol., 28(1):9-17 (1995).
Linder et al., “Histopathologic changes in the testes of rats exposed to dibromoacetic acid,” Reprod Toxicol., 11(1):47-56 (1997).
Linder et al., “Spermatotoxity of dichloroacetic acid,” Reprod Toxicol., 11(5)681-8 (1997).

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