Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1981-06-12
1983-03-22
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125LH, A61K 3700, C07C10352
Patent
active
043775748
ABSTRACT:
Peptides which are LRF analogs that inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads can be effective contraceptives when administered to male mammals. The peptides are LRF antagonists having a binding affinity at least about 15 times that exhibited by LRF and having an ICR.sub.50 of less than 1/l. Examples of peptides which may be used are those having the structure:
REFERENCES:
patent: 4218439 (1980-08-01), Rivier et al.
Bowers, et al., Biochem. & Biophys. Res. Commun. 72, (1976) pp. 1003-1007.
C. Rivier, et al., Endocrinology 108, (1981) pp. 1998-2001.
Chem. Abstr. 94, (1981) 25238n.
Chem. Abstr. 94, (1981) 41612k.
Chem. Abstr. 94, (1981) 41539s.
Chem. Abstr. 95, (1981) 91232c.
Chem. Abstr. 89, (1978) 157886d.
R. Lind, et al., Reversible Inhibition of Spermatogenesis, 305, pp. 663-667.
Science 210, (1980) pp. 93-94.
Acta Endocrinologica 91, (1979) pp. 601-608.
Rivier Catherine L.
Rivier Jean E. F.
Vale, Jr. Wylie W.
Phillips Delbert R.
The Salk Institute for Biological Studies
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