Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1990-01-29
1991-05-07
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424DIG14, 514635, 514841, 514843, A61K 3174, A61K 31155
Patent
active
050135449
ABSTRACT:
Pharmaceutical compositions comprising a combination of a polymeric biguanide and a spermicidal surfactant, useful for contraceptive purposes, for their spermicidal or sperm-immobilizing effect, and contraceptive methods and devices using them.
The polymeric biguanide is preferably a compound as described in U.K. Patent Specification No. 702,268 or a bisbiguanide as described in U.K. Patent Specification No. 705,838 or 1,095,902, but especially chlorhexidine. The spermicidal surfactant may be derived from ethylene oxide, preferably a condensate of nonylphenol and ethylene oxide, and especially with 9 to 11 molecular proportions thereof.
To avoid short-lived activity, the compositions are preferably made substantially free from anions (notably halide ions and especially chloride ions) which cause deactivation, apparently by reducing the solubility of the active ingredients.
REFERENCES:
patent: 4590070 (1986-05-01), Chantler et al.
patent: 4602042 (1986-07-01), Chantler et al.
patent: 4795761 (1989-01-01), Curtis-Prior
CA 104:162116k, "Comparison of Action of Nonoxynol-9 and Chlorhexidine on Sperm", Sharman et al. (1986).
CA 103: 206801r, "A Comparison of Effects of Nonoxynol-9 and Chlorhexidine on Sperm Motility", Louis et al. (1985).
Chantler Eric N.
Elstein Max
Lee Lester L.
Pili-Curtis Carmen
The Victoria University of Manchester
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