Contraceptive implant

Surgery – Female reproductory tract shields – supports – or birth... – With contraceptive – spermacidal – or antifertility agent

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Details

128833, 6048901, A61K 922

Patent

active

049571192

ABSTRACT:
The invention relates to an implant of polymeric material which can release a contraceptive agent for a relatively long time when fitted subcutaneously or locally. The implant comprises a core material of ethylene/vinyl acetate copolymer which functions as a matrix for a contraceptive substance, an ethylene/vinyl acetate membrane encasing the core material, and a contact layer at the interface of the core material and membrane which prevents the separation of the core material from the membrane. The implant of the invention is made by a co-extrusion process.

REFERENCES:
patent: 3903880 (1975-09-01), Higuchi et al.
patent: 4582052 (1986-04-01), Dunn et al.
patent: 4596576 (1986-06-01), de Nijs
patent: 4673565 (1987-06-01), Di Luccio et al.
patent: 4720384 (1988-01-01), Di Luccio et al.
D. N. Robertson et al., "Release Rates of Levonorgestrel from Silastic Capsules, Homogeneous Rods and Covered Rods in Humans," Chemical Abstracts, 99(8), pp. 308-309, 1983.
D. N. Robertson et al., "Release Rates of Levonorgestrel from Silastic Capsule Homogeneous Rods and Covered Rods in Humans," Contraception, 27(5), 483-495, 1983.
W. Losert et al., "Progestogens with Antimineralocorticoid Activity," Arzneim.-Forsch/Drug. Res., 35(I), No. 2 (1985).
M. J. D. Eenink et al., "Biodegradable Hollow Fibres for the Controlled Release of Hormones," J. of Controlled Release, 6, pp. 225-247 (1987).
Long Acting Contraceptive Delivery Systems, Zatuchni et al., "Implantable Levonorgestrel Rod Systems . . . ", Harper & Row, Phila., 1983, pp. 133-139.
Chemical Contraception, Bennett, John P., Columbia University Press, N.Y., 1974, pp. 56-58.

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