Contraceptive composition

Details Contraceptive composition Contraceptive composition

1987-03-06

1989-01-03

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

5142362, 514415, 514613, 514650, 514718, 514843, A61K 31135

Patent

active

047957611

ABSTRACT:
A contraceptive composition for application to the vagina of a female mammal comprising a contraceptive amount of a contraceptive combination, the combination containing a spermicidal or sperm-immobilizing polyethoxyethanol and a beta-adrenergic blocker (as herein before defined).
The polyethoxyethanol may be, for example, an octoxynol or, which is preferred, a nonoxynol, especially nonoxynol-9. The beta-adrenergic blocker is preferably a spermicidal or sperm-immobilizing beta-adrenergic blocker, propranolol (in particular the d-isomer) being especially preferred.
The composition may also contain a spermicidal or sperm-immobilizing preservative.

REFERENCES:
patent: 4277461 (1981-07-01), Lucker et al.
patent: 4384003 (1983-05-01), Kazmiroski et al.
patent: 4575558 (1986-03-01), Mai et al.
S. M. Louis, A Comparison of the Effects of Nonoxynol-9 and Chlorhexidine on Sperm Motility, Contraception, vol. 32, No. 2, 1985, pp. 199-205.
K. Rajkumar et al., Effect of Some Adrenergic Drugs on Fertility in Rats--A Preliminary Communication, Indian J. Med. Res. 67, 1978, pp. 478-481.

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