Contraceptive and menstrual cycle controlling drug having oncost

Details Contraceptive and menstrual cycle controlling drug having oncost Contraceptive and menstrual cycle controlling drug having oncost

1991-09-27

1993-12-21

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514181, 514415, 514843, A61K 3156, A61K 31405

Patent

active

052721418

ABSTRACT:
The present invention relates to a drug for human use, having contraceptive and menstrual cycle controlling properties, characterized in that the drug comprises N-acetyl-5-methoxytryptamine or melatonin, in a dose of 100-200 mg per day, N-acetyl-2-bromo-5-methoxytryptamine or 2-bromomelatonin in a dose of 25-50 mg per day, N-acetyl-2-iodo-5-methoxytryptamine or 2-iodomelatonin, in a dose of 20-40 mgs per day, in association with a progestine compound. The administration is carried out for 23 days, by using an association of 2-iodomelatonin and/or melatonin and/or 2-bromomelatonin and a progestinic compound, followed by 5 days in which only 2-iodomelatonin and/or melatonin and/or 2-bromomelatonin is administered; the drug having oncostatic preventive and therapeutic properties, in mammary tumours and melanomas, characterized by the use of 2-iodomelatonin, melatonin and 2-bromomelatonin respectively with doses of 20-40 mgs., 100-200 mgs., 25-50 mg per day; and the drug having moreover antikinetosic properties, and being characterized by the use of 2-iodomelatonin in a dose per day of 2.5 mg.; melatonin, in a dose per day of 10 mg and 2-bromomelatonin in a dose per day of 3.5 mg, either individually and/or in association with the acetyl coenzyme A-(AcCoA), in a dose of 8-10 mg per day.

REFERENCES:
patent: 4855305 (1989-08-01), Cohen

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