Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-07-01
1995-08-08
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514579, 514843, 546344, 558414, 558423, A61K 31435, C07D21330
Patent
active
054399130
ABSTRACT:
Competitive progesterone antagonists, including two novel steroids, viz., 11.beta.,19-[4-(cyanophenyl)-o-phenylene]-17.beta.-hydroxy-17.alpha.-(3-hy droxyprop-1(Z)-enyl)-4-androsten-3-one and 11.beta.,19-[4-(3-pyridinyl)-o-phenylene]-17.beta.-hydroxy-17.alpha.-(3-hy droxyprop-1(Z)-enyl)-4-androsten-3-one, inhibit formation of endometrial glands at below their ovulation inhibiting dose and the abortive dose, and thus achieve oral contraception in females without adversely affecting the menstrual cycle and without risk of aborting a previous implanted fertilized egg or a fetus.
REFERENCES:
patent: 5095129 (1992-03-01), Ottow et al.
T. Luukkainen et al., Fert. and Ster. vol. 49, No. 6, Jun. 1988, pp. 961-963.
L. Nieman et al., Baillier's Clin. Obst and Gyn., vol. 2, No. 3, pp. 609-616 Sep. 1988.
Swahn et al., Hum Reprod, vol. 5, No. 4, May 1990, pp. 402-408.
T. Kawano et al., Acta Obstet et Gyna Japonica, Vo., 41, No. 10, Oct. 1989, pp. 1507-1511.
M. Batista et al., Am J of Obstst and Gyne, vol. 165, No. 1, pp. 82-86 Jul. 1991.
Batista et al., "Daily Administration of the progesterone antagonist RU 486 prevents implantation . . . etc.", Am. J. Obstet. Gynecol., vol. 165, No. 1, pp. 82-86, Jul. 1991.
Batista et al., "Delayed endometral maturation induced by daily administration of the antiprogestin RU 486 . . ., etc.", Am. J. Obstet. Gynecol., Vo. 167, No. 1, pp. 60-65, Jul. 1992.
Chwalisz Krzystof
Elger Walter
Ottow Eckhard
Schmidt-Gollwitzer Karin
Ivy C. Warren
Owens A. A.
Schering Aktiengesellschaft
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