Contraception method using competitive progesterone antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514579, 514843, 546344, 558414, 558423, A61K 31435, C07D21330

Patent

active

054399130

ABSTRACT:
Competitive progesterone antagonists, including two novel steroids, viz., 11.beta.,19-[4-(cyanophenyl)-o-phenylene]-17.beta.-hydroxy-17.alpha.-(3-hy droxyprop-1(Z)-enyl)-4-androsten-3-one and 11.beta.,19-[4-(3-pyridinyl)-o-phenylene]-17.beta.-hydroxy-17.alpha.-(3-hy droxyprop-1(Z)-enyl)-4-androsten-3-one, inhibit formation of endometrial glands at below their ovulation inhibiting dose and the abortive dose, and thus achieve oral contraception in females without adversely affecting the menstrual cycle and without risk of aborting a previous implanted fertilized egg or a fetus.

REFERENCES:
patent: 5095129 (1992-03-01), Ottow et al.
T. Luukkainen et al., Fert. and Ster. vol. 49, No. 6, Jun. 1988, pp. 961-963.
L. Nieman et al., Baillier's Clin. Obst and Gyn., vol. 2, No. 3, pp. 609-616 Sep. 1988.
Swahn et al., Hum Reprod, vol. 5, No. 4, May 1990, pp. 402-408.
T. Kawano et al., Acta Obstet et Gyna Japonica, Vo., 41, No. 10, Oct. 1989, pp. 1507-1511.
M. Batista et al., Am J of Obstst and Gyne, vol. 165, No. 1, pp. 82-86 Jul. 1991.
Batista et al., "Daily Administration of the progesterone antagonist RU 486 prevents implantation . . . etc.", Am. J. Obstet. Gynecol., vol. 165, No. 1, pp. 82-86, Jul. 1991.
Batista et al., "Delayed endometral maturation induced by daily administration of the antiprogestin RU 486 . . ., etc.", Am. J. Obstet. Gynecol., Vo. 167, No. 1, pp. 60-65, Jul. 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Contraception method using competitive progesterone antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Contraception method using competitive progesterone antagonists , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Contraception method using competitive progesterone antagonists will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-971340

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.