Contraception in female primates without affecting the menstrual

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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514255, 514256, 514277, 514299, 514300, 514361, 514362, 514363, 514364, 514372, 514374, 514378, 514381, 514383, 514384, 514393, 514394, 514396, 514401, 514469, 514843, A61K 3156, A61K 31495, A61K 31505, A61K 31435, A61K 3144, A61K 3141, A61K 31425, A61K 3142, A61K 31415, A61K 3134

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055831281

ABSTRACT:
The invention relates to the use of aromatase inhibitors for contraception in female primates and to a method for contraception in female primates using such substances and to the use of those substances for the preparation of pharmaceutical compositions for contraception in female primates.

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Brodie et al.; J. Steroid Biochemistry, 11, 107-112 (1979) "Aromatase Inhibitors and Their Use in Controlling Estrogen Dependent Processes".
Wu et al; J. Reprod. Fert. 66, 655-662 (1982) "Effect of Aromatase Inhibitor on Estrogen Production in Rabbit Blastocytes".
Steele et al; Steroids 50, 147-161 (1986) "In Vitro & In Vivo Studies Demonstrating Potent and Selective Estrogen Inhibition with the non-steroidal Aromatase Inhibitor CGS16949A."
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Brodie et al; Endocrinology 100: 1684-1695. "The Effect of an Aromatase Inhibitor, 4-hydroxy-4-Androstene-3,17-Dione on Estrogen Dependent Processes in Reproduction and Brest Cancer." (1975).
Mead et al. Biology of Reproduction 22, 560-565 (1980) "Aromatase Activity in the Corpora Lutea of the Ferret."
Moudgal et al; Biology of Reproduction 1991 (Abstract) "Contraceptive Efficacy of an Aromatase Inhibitor (CGS 16949A) as analyzed in the Bonnet Monkey."
Gosh et al; Biology of Reproduction 40, Suppl. 1, 122. "Effect of an Aromatase Inhibitor (4-hydroxyandrostenedione) in Pre-Implantation Hamster Embryos" (1989).
Derwent Abstract of EP 277910; Aug. 1988.

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