Continuous selective clonogenic expansion of relatively undiffer

Details Continuous selective clonogenic expansion of relatively undiffer Continuous selective clonogenic expansion of relatively undiffer

1995-05-19

1997-10-07

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435366, 435374, 435376, 435377, 435395, 435403, 5033871, C12N 502, C12N 508, C07K 1628

Patent

active

056747500

ABSTRACT:
A system is provided for selective clonogenic expansion of relatively undifferentiated cells, including (a) a tube containing a plurality of beads of a size which permits a plurality of the undifferentiated cells to grow thereon, the beads bearing on their surfaces a selective binding molecule which binds to a surface antigen present on the relatively undifferentiated cells, wherein the antigen is not present on the surfaces of the relatively differentiated cells; (b) means for continuously providing nutrients to the relatively undifferentiated cells growing on the beads, wherein the nutrients are delivered via a fluid which flows through the tube and past the beads; and (c) means for continuously harvesting the relatively undifferentiated cells downstream of the beads.

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Mayani et al. (1993) Blood. vol. 81(12) : 3252-3258.

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