Continuous release pharmaceutical compositions

Details Continuous release pharmaceutical compositions Continuous release pharmaceutical compositions

1991-08-22

1994-11-22

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424423, 514 13, 514 14, 514 15, A61K 4734, A61K 952

Patent

active

053667344

ABSTRACT:
Pharmaceutical compositions, comprising a polylactide and a pharmacologically active, acid stable polypeptide, which when placed in an aqueous physiological environment release the polypeptide at an approximately constant rate in an essentially monophasic manner, with a minimal, or no induction period prior to the release; polylactides suitable for use in said compositions; and a method for the manufacture of such polylactides.

REFERENCES:
patent: 2703316 (1955-03-01), Schneider
patent: 3773919 (1973-11-01), Boswell
patent: 3887699 (1975-06-01), Yolles
patent: 4001388 (1977-01-01), Shell
patent: 4011312 (1977-03-01), Reuter et al.
patent: 4033938 (1977-07-01), Augert
patent: 4234571 (1980-11-01), Nestor et al.
patent: 4293539 (1981-10-01), Ludwig et al.
patent: 4419340 (1983-12-01), Yolles
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4675189 (1987-06-01), Kent et al.
Sanders et al, Journal of Pharmaceutical Sciences, vol. 73, No. 9, pp. 1294-1297 (Sep. 1984).
Robinson, "Sustained and Controlled Release Drug Delivery Systems", Marcell Dekker, Inc., New York.
Baker, "Controlled Release of Bioactive Materials", Academic Press, New York (1980).
Beck et al, Acta of Europaea Fertilitatis.
Nixon, "Microencapsulation", Marcell Dekker, Inc., New York.
Kondo, "Microcapsule Processing and Technology", Marcel Dekker, Inc., New York.

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