Continuous release pharmaceutical compositions

Details Continuous release pharmaceutical compositions Continuous release pharmaceutical compositions

1991-07-22

1994-06-14

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 530410, 530411, 530406, 514964, 514965, A61K 3702

Patent

active

053208404

ABSTRACT:
Pharmaceutical compositions for continuous release of a physiologically active substance in which the physiologically active substance comprises a polypeptide covalently conjugated to a water soluble polymer show particularly desirable release characteristics. Polypeptides for use in the pharmaceutical compositions include G-CSF and solution stable derivatives thereof, human calcitonin and interleukin-2. The material of the composition may be a polylactide or biodegradable hydrogel derived from an amphipathic block copolymer.
The compositions enable a therapeutically effective polypeptide to be continuously released over a prolonged period of time following a single administration of the pharmaceutical composition to a patient.

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