Continuous release formulations

Details Continuous release formulations Continuous release formulations

1983-04-15

1985-07-02

Lieberman, Allan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 541, 525 542, 525154, 525386, 525403, 525405, 525450, 525462, 525472, 525 57, 527200, 527300, C08L 502, C08L 5100, C08L 7102, C08L 7900

Patent

active

045269386

ABSTRACT:
Pharmaceutical compositions comprising a pharmacologically active polypeptide and a pharmacologically or veterinarily acceptable amphipathic, non-cross-linked linear, branched or graft block copolymer, which has a minimum weight average molecular weight of 5,000, in which the hydrophobic component is biodegradable and the hydrophilic component may or may not be biodegradable, the composition being capable of absorbing water to form a hydrogel when placed in an aqueous, physiological-type environment; copolymers suitable for use in said compositions; and method for the manufacture of such copolymers.

REFERENCES:
patent: 3773919 (1973-11-01), Boswell
patent: 3887699 (1975-06-01), Yolles
patent: 4045418 (1977-08-01), Sinclair
patent: 4157437 (1979-06-01), Okazumi
patent: 4243775 (1981-01-01), Rosensaft
patent: 4279249 (1981-07-01), Vert
patent: 4429080 (1984-01-01), Casey
Remingtons Pharmaceutical Sciences, Mack Publ. Co., (1975), pp. 1618-1631.
Jackanicz et al., Contraception, 1973, (8), 227-234.
Anderson et al., Contraception, 1976, (11), 375-384.
Wise et al., Life Sciences, 1976, (19), 867-874.
Woodland et al., J. of Medicinal Chemistry, 1973, 16, 897-901.
Wise et al., Bulletin of the Parenteral Drug Assn., 1976, (30), pp. 306-312.

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