Continuous process for the production of lactulose from lactose

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536127, C07H 100

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058958142

ABSTRACT:
A method is described for the preparation of lactulose by isomerizing lactose to lactulose, followed by complexing lactulose to boric acid. The isomerization reaction is carried out in alkaline solution, and it is followed by splitting the lactulose-borate complex in acidic solution and separating the two components. Separation is achieved by crystallizing boric acid, filtering the crystals out of the product mixture, evaporating the product mixture to form a concentrate, recirculating the concentrate to the crystallization step where it is mixed with fresh reaction mixture in order to provide volume and nuclei for the crystallization of the boric acid in the reaction mixture, then passing the resulting mixture through another filtration step followed by an additional separation step by column chromatography.

REFERENCES:
patent: 4273922 (1981-06-01), Hicks
Hicks and Parrish, "A New Method for the Preparation of Lactulose from Lactose", Carbohydrate Research, vol. 82, pp. 393-397 (1980).
Kozempel and Kurantz, "The Isomerization Kinetics of Lactose to Lactulose in the Presence of Borate", J. Chem. Tech. Biotechnol., vol. 59, pp. 25-29 (1994).
Hicks et al., "Synthesis and High-Performance Liquid Chromatography of Maltulose and Cellobiulose", Carbohydrate Research, vol. 112, pp. 37-50 (1983).
Hicks et al., Removal of Boric Acid and Related Compounds from Solutions of Carbohydrates with Borun-Selective Resin (IRA-743), Carbohydrate Research, vol. 147, pp. 39-48 (1986).
Kozempel and Kurantz, "A Continuous Reactor System for Production of Lactulose", J. Chem. Tech. Biotechnol., vol. 59, pp. 265-269 (1994).

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