Continuous process for the preparation of fructopyranose...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C536S017600, C549S426000, C558S048000

Reexamination Certificate

active

10691782

ABSTRACT:
The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I)wherein R1, R3, R4, R5, R6and X are as herein defined. The present invention is further directed to a continuous process for the preparation of Topiramate.

REFERENCES:
patent: 4513006 (1985-04-01), Maryanoff et al.
patent: 5387700 (1995-02-01), Maryanoff et al.
Maryanoff, B.E. et al.: “Structure-Activity Studies on anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives”. Journal of Medicinal Chemistry, American Chemical Society. Washington, U.S., vol. 41, No. 8, 1998, pp. 1315-1343.
Kyowa, H.: “Topiramate”. Drugs of the Future, Barcelona, ES, vol. 21, No. 4, 1996, pp. 463-465.

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