Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-03-27
2007-03-27
Dentz, Bernard (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C536S017600, C549S426000, C558S048000
Reexamination Certificate
active
10691782
ABSTRACT:
The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I)wherein R1, R3, R4, R5, R6and X are as herein defined. The present invention is further directed to a continuous process for the preparation of Topiramate.
REFERENCES:
patent: 4513006 (1985-04-01), Maryanoff et al.
patent: 5387700 (1995-02-01), Maryanoff et al.
Maryanoff, B.E. et al.: “Structure-Activity Studies on anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives”. Journal of Medicinal Chemistry, American Chemical Society. Washington, U.S., vol. 41, No. 8, 1998, pp. 1315-1343.
Kyowa, H.: “Topiramate”. Drugs of the Future, Barcelona, ES, vol. 21, No. 4, 1996, pp. 463-465.
Adkins Thomas W.
Cicco Charles F.
Feibush Penina
Koch Donald A.
Maryanoff Cynthia
Appollina Mary
Dentz Bernard
Ortho-McNeil Pharmaceutical , Inc.
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