Continuous process for preparing 4-aminopiperidines

Details Continuous process for preparing 4-aminopiperidines Continuous process for preparing 4-aminopiperidines

1998-02-05

1999-08-31

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

502337, C07D21156

Patent

active

059455365

ABSTRACT:
N-monosubstituted 4-aminopiperidine is prepared by a process comprising, in a single stage, continuously passing a 4-oxopiperidine and a primary amine over a metal hydrogenation catalyst under a hydrogen partial pressure of 1-500 bar at a LHSV of up to 1 hr.sup.-1.

REFERENCES:
patent: 5773622 (1998-06-01), Jegelka et al.
Chemical Abstract vol. 87 No. 135095, Kintopt et al, Redution of 4-oxopiperidine to 4-hydrogen piperidine, 1977.

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