Continuous process for manufacture of lactide polymers with puri

Details Continuous process for manufacture of lactide polymers with puri Continuous process for manufacture of lactide polymers with puri

1993-09-16

1994-10-18

Kight, III, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From carboxylic acid or derivative thereof

525415, 526 67, 526 68, 528357, 549274, C08G 6308, C07D31912

Patent

active

053570359

ABSTRACT:
A process for the continuous production of polylactide polymers from lactic acid which incorporates removal of water or a solvent carrier to concentrate the lactic acid feed followed by polymerization to a low-molecular-weight prepolymer. This prepolymer is fed to a reactor in which a catalyst is added to facilitate generation of lactide, the depolymerization product of polylactic acid. The lactide generated is continuously fed to a distillation system as a liquid or vapor wherein water and other impurities are removed. The resultant purified liquid lactide is fed directly to a polymerization process.

REFERENCES:
patent: 1095205 (1914-05-01), Gruter et al.
patent: 1849107 (1932-03-01), Moss
patent: 1995970 (1934-04-01), Dorough
patent: 2396994 (1946-03-01), Filachione et al.
patent: 2703316 (1955-03-01), Schneider
patent: 2758987 (1956-08-01), Salzberg
patent: 2951828 (1960-09-01), Zeile et al.
patent: 3268487 (1966-08-01), Klootvijk
patent: 3322791 (1967-05-01), Selman
patent: 3531561 (1970-09-01), Trehu
patent: 3636956 (1972-01-01), Schneider
patent: 3772420 (1973-11-01), Glick et al.
patent: 3773919 (1973-11-01), Boswell et al.
patent: 3839297 (1974-10-01), Wassermann et al.
patent: 3887699 (1975-06-01), Yolles
patent: 3912692 (1975-10-01), Casey et al.
patent: 4045418 (1977-08-01), Sinclair
patent: 4249531 (1981-02-01), Heller et al.
patent: 4273920 (1981-06-01), Nevin
patent: 4279249 (1981-07-01), Vert et al.
patent: 4595713 (1986-06-01), St. John
patent: 4643734 (1987-02-01), Lin
patent: 4677191 (1987-06-01), Tanaka et al.
patent: 4683288 (1987-07-01), Tanaka et al.
patent: 4719246 (1988-01-01), Murdoch et al.
patent: 4727163 (1988-02-01), Bellis
patent: 4728721 (1988-03-01), Yamamoto et al.
patent: 4766182 (1988-08-01), Murdoch et al.
patent: 4789726 (1988-12-01), Hutchinson
patent: 4797468 (1989-01-01), DeVries
patent: 4800219 (1989-01-01), Murdoch et al.
patent: 4835293 (1989-05-01), Bhatia
patent: 4902515 (1990-02-01), Loomis et al.
patent: 4950258 (1990-08-01), Kawai et al.
patent: 4960866 (1990-10-01), Bendix et al.
patent: 4966982 (1990-10-01), Ono et al.
patent: 4981696 (1991-01-01), Loomis et al.
patent: 4983745 (1991-01-01), Muller et al.
patent: 4990222 (1991-02-01), Aigner et al.
patent: 5011946 (1991-04-01), Hess et al.
patent: 5023349 (1991-06-01), Bhatia
patent: 5023350 (1991-06-01), Bhatia
patent: 5028667 (1991-07-01), McLain et al.
patent: 5041529 (1991-08-01), Shinoda et al.
patent: 5043458 (1991-08-01), Bhatia
patent: 5053485 (1991-10-01), Nieuwenhuis et al.
patent: 5053522 (1991-10-01), Muller
patent: 5076983 (1991-12-01), Loomis et al.
patent: 5097005 (1992-03-01), Tietz
patent: 5108399 (1992-04-01), Eitenmuller et al.
patent: 5132397 (1992-07-01), DeGuia
patent: 5134171 (1992-07-01), Hammel et al.
patent: 5136017 (1992-08-01), Kharas et al.
patent: 5136057 (1992-08-01), Bhatia
patent: 5142023 (1992-08-01), Gruber et al.
patent: 5149833 (1992-09-01), Hess et al.
patent: 5180765 (1992-01-01), Sinclair
patent: 5210296 (1993-05-01), Cockrem et al.
patent: 5229528 (1993-07-01), Brake et al.
patent: 5236560 (1993-08-01), Drysdale
patent: 5247058 (1993-09-01), Gruber et al.
patent: 5247059 (1993-09-01), Gruber et al.
patent: 5258488 (1993-11-01), Gruber et al.
W. Carothers, G. Dorough, and F. Van Natta ("Studies of Polymerization and Ring Formation. X. The Reversible Polymerization of Six-Membered Cyclic Esters", 1932, American Chemical Society Journal, v. 54, pp. 761-772).
E. Filachione, E. Costello, T. Dietz and C. Fisher ("Lactic Acid Derivatives as Plasticizers Esters of Polymeric Lectic Acid", 1951, Bur. Agric. Ind. Chem., v. 11, pp. 1-11).
D. Deane and E. Hammond ("Coagulation of Milk for Cheese-Making by Ester Hydrolysis", 1960, Journal of Dairy Science, v. 43, pp. 1421-1429).
Kulkarni et al. ("Biodegradable Poly(lactic acid) Polymers", 1971, J. Biomed. Mater. Res., v. 5, pp. 169-181).
A. Schindler, R. Jeffcoat, G. Kimmel, C. Pitt, M. Wall and R. Zweidinnger ("Biodegradable Polymers for Sustained Drug Delivery", 1977, Contemporary Topics in Polymer Science, v. 2, pp. 251-287).
I. Luderwald ("Thermal Degradation of Polyesters in the Mass Spectrometer", 1979, Dev. Polymer Degradation, v. 2, pp. 77-98).
M. Vert and F. Chabot ("Stereoregular Bioresorbable Polyesters for Orthopaedic Surgery", 1981, Makromol. Chem., Supp. 5, pp. 30-41).
M. Gupta and V. Deshmukh ("Thermal Oxidative Degradation of Poly-latic Acid; Part I: Activation Energy of Thermal Degradation in Air", 1982, Colloid & Polymer Science, v. 260, pp. 308-311).
M. Gupta and V. Deshmukh ("Thermal Oxidative Degradation of Poly-lactic Acid; Part II: Molecular Weight and Electronic Spectra During Isothermal Heating", 1982, Colloid & Polymer Science, v. 260, pp. 514-517).
G. Van Hummel and S. Harkema ("Structure of 3,6-Dimethyl-1,4-Dioxane-2,5-Dione [D-,D-{L-,L-}Lactide]", 1982, Acta. Crystallogr., v. B38, pp. 1679-1681).
F. Chabot, M. Vert, S. Chapelle and P. Granger ("Configurational Structures of Lactic Acid Stereocopolymers as Determined by .sup.13 C(.sup.1 H) N.M.R.", 1983, Polymer, v. 24, pp. 53-59).
F. Kohn, J. Van Don Berg, G. Van De Ridder and J. Feijen ("The Ring-Opening Polymerization of D,L-Lactide in the Melt Initiated with Tetraphenyltin", 1984, Journal of Applied Polymer Science, v. 29, pp. 4265-4277).
H. Kricheldorf and A. Serra ("Polylactones 6. Influence of Various Metal Salts on the Optical Purity of Poly(L-lactide)", 1985, Polymer Bulletin, v. 14, pp. 497-502).
A. Chavla and T. Chang ("In-Vivo Degradation of Poly(lactic acid) of Different Molecular Weights", 1985, Biomat., Med. Dev., Art. Org., v. 13, pp. 153-162).
I. McNeill and H. Leiper ("Degradation Studies of Some Polyesters and Polycarbonates--1. Polylactide: General Features of the Degradation Under Programmed Heating Conditions", 1985, Polymer Degradation and Stability, v. 11, pp. 267-285).
I. McNeill and H. Leiper ("Degradation Studies of Some Polyesters and Polycarbonates--2. Polylactide: Degradation Under Isothermal Conditions, Thermal Degradation Mechanism and Photolysis of the Polymer", 1985, Polymer Degradation and Stability, v. 11, pp. 309-326).
Makino et al. ("Preparation and in Vitro Degradation Properties of Polylactide Microcapsules", 1985, Chem. Pharm. Bull., v. 33, pp. 1195-1201).
D. Garozzo, M. Giuffrida and G. Montaudo ("Primary Thermal Decomposition Processes in Aliphatic Polyesters Investigated by Chemical Ionization Mass Spectrometry", 1986, Macromolecules, v. 19, pp. 1643-1649).
"Irganox.RTM. 1076 Antioxidant and Thermal Stabilizer", (published on an unknown date in 1986 by Ciba-Geigy Corporation, Three Skyline Drive, Hawthorne, N.Y. 10532).
J. Leenslag and A. Pennings ("Synthesis of high-molecular-weight poly(L-lactide) initiated with tin 2-ethylhexanoate", 1987, Makromol. Chem., v. 188, pp. 1809-1814).
Nakamura et al. ("Surgical Application of Biodegradable Films Prepared from Lactide-.epsilon.-Caprolactone Copolymers ", 1987, Bio. Materials and Clinical Applications, v. 7, pp. 759-764).
H. Kricheldorf, M. Berl and N. Scharnagl ("Polymerization Mechanism of Metal Alkoxide Initiated Polymerizations of Lactide and Various Lactones", 1988, Makromol., v. 21, pp. 286-293).
K. Jamshidi, S. Hyon and Y. Ikada ("Thermal Characterization of Polylactides", 1988, Polymer, v. 29, pp. 2229-2234).
M. Vert ("Bioresorbable Polymers for Temporary Therapeutic Applications, 1989, Die Angvandte Makromolekulare Chemie, v. 166-167, pp. 155-168).
"Hydrolytic Stability/Corrosivity of Phosphite Costabilizers", (Technical Bulletin 89-04, published on an unknown date in 1989, by Stars Laboratory, Additives Division, Ciba-Geigy Corporation, Ardsley, N.Y. 10502).
"GE Specialty Chemicals Product Guide CA -4001E", (published on an unknown date in 1989, by General Electric Company, 5th and Avery Street, Parkersburg, WV 26102).
"Tinuvin.RTM. 123 Hindered Aminoether Light Stabilizer for Coatings", (published on an unknown date in 1989, by Ciba-Geigy Corporation, Three Skyline Drive, Hawthorne, N.Y. 10532).
"Irganox.RTM. B-Blends Antioxidants and Process Stabilizers for Polymers", (published on an unknown date in March, 1990, by Ciba-

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