Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From carboxylic acid or derivative thereof
Patent
1992-08-24
1993-12-28
Kight, III, John
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
From carboxylic acid or derivative thereof
525415, 526 68, 528357, 549274, C08G 6308, C07D31912
Patent
active
052740730
ABSTRACT:
A process for the continuous conversion of crude lactic acid to a substantially purified lactide or polylactide including the steps of polymerizing the lactic acid to form a prepolymer with subsequent depolymerization to form a crude lactide in the presence of a catalyst. The crude lactide is purified in an improved distillation system in which at least three fractions are formed with the substantially purified lactide removed as an intermediate boiling sidedraw stream. The substantially purified lactide may then be polymerized.
REFERENCES:
patent: 1095205 (1914-05-01), Grater et al.
patent: 1849107 (1932-03-01), Moss
patent: 1995970 (1935-03-01), Dorough
patent: 2396994 (1946-03-01), Filachione et al.
patent: 2703316 (1955-03-01), Schneider
patent: 2758987 (1956-08-01), Salzberg
patent: 2951828 (1960-09-01), Zeile et al.
patent: 3268487 (1966-08-01), Klootwijk
patent: 3322791 (1967-05-01), Selman
patent: 3531561 (1970-09-01), Trehu
patent: 3636956 (1972-01-01), Schneider
patent: 3772420 (1973-11-01), Glick et al.
patent: 3773919 (1973-11-01), Boswell et al.
patent: 3839297 (1974-10-01), Wassermann et al.
patent: 3887699 (1975-06-01), Yolles
patent: 3912692 (1975-10-01), Casey et al.
patent: 4045418 (1977-08-01), Sinclair
patent: 4249531 (1981-02-01), Heller et al.
patent: 4273920 (1981-06-01), Nevin
patent: 4279249 (1981-07-01), Vert et al.
patent: 4595713 (1986-06-01), St. John
patent: 4643734 (1987-02-01), Lin
patent: 4677191 (1987-06-01), Tanaka et al.
patent: 4683288 (1987-07-01), Tanaka et al.
patent: 4719246 (1988-01-01), Murdoch et al.
patent: 4727163 (1988-02-01), Bellis
patent: 4728721 (1988-03-01), Yamamoto et al.
patent: 4766182 (1988-08-01), Murdoch et al.
patent: 4789726 (1988-12-01), Hutchinson
patent: 4797468 (1989-01-01), De Vries
patent: 4800219 (1989-01-01), Murdoch et al.
patent: 4835293 (1989-05-01), Bhatia
patent: 4902515 (1990-02-01), Loomis et al.
patent: 4950258 (1990-08-01), Kawai et al.
patent: 4960866 (1990-10-01), Bendix et al.
patent: 4981696 (1991-01-01), Loomis et al.
patent: 4983745 (1991-01-01), Muller et al.
patent: 4990222 (1991-02-01), Aigner et al.
patent: 5011946 (1991-04-01), Hess et al.
patent: 5023349 (1991-06-01), Bhatia
patent: 5023350 (1991-06-01), Bhatia
patent: 5028667 (1991-07-01), McLain et al.
patent: 5041529 (1991-08-01), Shinoda et al.
patent: 5043458 (1991-08-01), Bhatia
patent: 5053485 (1991-10-01), Niewenhais et al.
patent: 5053485 (1991-10-01), Nieuwenhuis et al.
patent: 5053522 (1991-10-01), Muller
patent: 5076983 (1991-12-01), Loomis et al.
patent: 5097005 (1992-03-01), Tietz
patent: 5108399 (1992-04-01), Eitenmuller et al.
patent: 5132397 (1992-07-01), DeGuia
patent: 5134171 (1992-07-01), Hammel et al.
patent: 5136017 (1992-08-01), Kharas et al.
patent: 5142023 (1992-08-01), Gruber et al.
patent: 5149833 (1992-09-01), Hess et al.
patent: 5180765 (1992-01-01), Sinclair
T. M. Jackanicz, "Polylactic Acid as a Biodegradable Carrier for Contraceptive Steroids", Contraception, vol. 8, No. 3, 227-234 (1973).
A. D. Schwope et al., "Lactic/Glycolic Acid Polymers as Narcotic Antagonist Delivery Systems", Life Sciences, vol. 17, 1877-1886 (1975).
L. C. Anderson, "An Injectable Sustained Release Fertility Control System", Contraception, vol. 13, No. 3, 375-384 (1976).
D. L. Wise et al., "Sustained Release of an Antimalarial Drug Using a Copolymer of Glycolic/Lactic Acid", Life Sciences, vol. 19, 867-874 (1976).
R. A. Miller et al., "Degradation Rates of Resorbable Implants (Polylactates and Polyglycolates): Rate Modification with Changes in Pla/Pga Copolymer Rations", J. Biomed. Mater. Res., vol. 11, 711-719 (1977).
D. K. Gilding et al., "Biodegradable Polymers for Use in Surgery--Polyglycolic/Polylactic Acid Homo and Copolymers: 1. Polymer, vol. 2, 1459-1464 (1979).
D. K. Gilding, "Degradation of Polymers: Mechanisms and Implications for Biomedical Applications", Biocompatibility of Clinical Implant Materials, D. F. Williams, ed., vol. 1, 43-65 (1981).
A. M. Reed and D. K. Gilding, "Biodegradable Polymers for Use in Surgery Polyglycolic/Polylactic Acid Homo and Copolymers: 2. In Vitro Degradation", Polymer, vol. 22, No. 4, 494-498 (1981).
D. K. Gilding, "Biodegradable Polymers", Biocompatibility of Clinical Implant Materials, D. F. Williams, ed., vol. 2, 209-232 (1981).
J. D. Strobel, "Biodegradable Polymers", paper presented at Medical Textiles and Biomedical Polymers and Materials Conference held at Clemson, S.C., U.S.A., Dec. 5-6, 1989, Stolle Research and Development Corp., PD 712-01, pp. 1-32 and Attachments A1-A21.
"Biocompatible Composite Would Be Completely Absorbed in the Body", Advanced Materials, vol. 12, No. 15, Aug. 1990, p. 6.
"Polylactides Exhibit Degradability", Tappi Journal, Sep. 1991, p. 42.
P. V. Bonsignore et al., 1992, "Poly(lactic acid) Degradable Plastics, Coatings and Binders", TAPPI Proceedings (Nonwovens Conference); pp. 129-140.
W. Carothers, G. Dorough, and F. Van Natta ("Studies of Polymerization and Ring Formation, X. The Reversible Polymerization of Six-Membered Cyclic Esters", 1932, American Chemical Society Journal, v. 54, pp. 761-772).
E. Filachione, E. Costello, T. Dietz and C. Fisher ("Lactic Acid Derivatives as Plasticizers Esters of Polymeric Lactic Acid", 1951, Bur. Agric. Ind. Chem., v. 11, pp. 1-11).
D. Deane and E. Hammond ("Coagulation of Milk for Cheese-Making by Ester Hydrolysis", 1960, Journal of Dairy Science, v. 43, pp. 1421-1429).
Kulkarni et al. ("Biodegradable Poly(lactic acid) Polymers", 1971, J. Biomed. Mater. Res., v. 5, pp. 169-181).
A. Schindler, R. Jeffcoat, G. Kimmel, C. Pitt, M. Wall and R. Zweidinnger ("Biodegradable Polymers for Sustained Drug Delivery", 1977, Contemporary Topics in Polymer Science, v. 2, pp. 251-287).
I. Luderwald ("Thermal Degradation of Polyesters in the Mass Spectrometer", 1979, Dev. Polymer Degradation, v. 2, pp. 77-98).
M. Vert and F. Chabot ("Stereoregular Bioresorbable Polyesters for Orthopaedic Surgery", 1981, Makromol. Chem., Supp. 5, pp. 30-41).
M. Gupta and V. Deshmukh ("Thermal Oxidative Degradation of Poly-lactic Acid; Part I: Activation Energy of Thermal Degradation in Air", 1982, Colloid & Polymer Science, v. 260, pp. 308-311).
M. Gupta and V. Deshmukh ("Thermal Oxidative Degradation of Poly-lactic Acid; Part II: Molecular Weight and Electronic Spectra During Isothermal Heating", 1982, Colloid & Polymer Science, v. 260, pp. 514-517).
G. Van Hummel and S. Harkema ("Structure of 3,6-Dimethyl-1,4-Dioxane-2,5-Dione [D-,D-{L-,L-}Lactide]", 1982, Acta. Crystallogr., v. B38, pp. 1679-1681).
F. Chabot, M. Vert, S. Chapelle and P. Granger ("Configurational Structures of Lactic Acid Stereocopolymers as Determined by .sup.13 C(.sup.1 H) N.M.R.", 1983, Polymer, v. 24, pp. 53-59).
F. Kohn, J. Van Don Berg, G. Van De Ridder and J. Feijen ("The Ring-Opening Polymerization of D,L-Lactide in the Melt Initiated with Tetraphenyltin", 1984, Journal of Applied Polymer Science, v. 29, pp. 4265-4277).
H. Kricheldorf and A. Serra ("Polylactones 6. Influence of Various Metal Salts on the Optical Purity of Poly(L-lactide)", 1985, Polymer Bulletin, v. 14, pp. 497-502).
A. Chawla and T. Chang ("In-Vivo Degradation of Poly(lactic acid) of Different Molecular Weights", 1985, Biomat., Med. Dev., Art. Org., v. 13, pp. 153-162).
I. McNeill and H. Leiper ("Degradation Studies of Some Polyesters and Polycarbonates--1. Polylactide: General Features of the Degradation Under Programmed Heating Conditions", 1985, Polymer Degradation and Stability, v. 11, pp. 267-285).
I. McNeill and H. Leiper ("Degradation Studies of Some Polyesters and Polycarbonates--2. Polylactide: Degradation Under Isothermal Conditions, Thermal Degradation Mechanism and Photolysis of the Polymer", 1985, Polymer Degradation and Stability, v. 11, pp. 309-326).
Makino et al. ("Preparation and in Vitro Degradation Properties of Polylactide Microcapsules", 1985, Chem. Pharm. Bull., v. 33, pp. 1195-1201).
D. Garozzo, M. Giuffrida and G. Montaudo ("Primary Thermal Decomposition Processes in Aliphatic Polyesters Investigated by Chemical Ionization Mass Spectrometry", 1986, Macromolecules, v. 19, pp. 1643-1649)
Benson Richard D.
Borchardt Ronald L.
Gruber Patrick R.
Hall Eric S.
Iwen Matthew L.
Cargill Incorporated
Dodson Shelley A.
Kight III John
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