Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1988-04-15
1991-03-12
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 530383, 530399, 530422, 530427, 435 691, 435 6951, 435 694, C07K 312, C07K 328, C07K 1526, C07K 1508
Patent
active
049994220
ABSTRACT:
A process is disclosed for continuously treating a solubilized protein solution containing a protein unfolded to some degree, in a small volume continuous flow reactor, to obtain the protein in a conformation exhibiting the protein's characteristic biological activity by continuously diluting out the solubilizing agent, while continuously withdrawing the refolded protein. The continuous process may be carried out using deionized water as a diluent, rather than buffer solutions.
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patent: 4017600 (1977-04-01), Stewart et al.
patent: 4427658 (1984-01-01), Maubois, Jr. et al.
patent: 4511502 (1985-04-01), Builder et al.
patent: 4828989 (1989-05-01), Prior et al.
Biogen N.V.
Furman Keith C.
Haley, Jr. James F.
Moskowitz Margaret
Yankwich Leon R.
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