Continuous lymphocyte cell lines, their production and use

Details Continuous lymphocyte cell lines, their production and use Continuous lymphocyte cell lines, their production and use

1983-07-05

1987-03-24

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435240, 4351721, 435948, 935 52, C12P 2100, C12N 500, C12N 1500, C12R 191

Patent

active

046525220

ABSTRACT:
A method for producing continuous B lymphocyte cell lines and monoclonal antibodies by such lines is provided. DNA isolated from neoplastic cells is introduced into stimulated lymphocytes. Individual cells that have been transformed by the added DNA and that produce antibodies are clonally expanded. Cultures of these continuous cells are employed to produce monoclonal antibodies.

REFERENCES:
patent: 4001080 (1977-01-01), Goust et al.
patent: 4108983 (1978-08-01), Wallack
patent: 4172124 (1979-10-01), Koprowski et al.
patent: 4195074 (1980-03-01), Safford, Jr.
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4271145 (1981-06-01), Wands et al.
patent: 4332893 (1982-06-01), Rosenberg
patent: 4334016 (1982-06-01), Furukawa
patent: 4464465 (1984-08-01), Lostrom
patent: 4529694 (1985-07-01), Lazarus et al.
patent: 4565687 (1986-01-01), Khazaeli et al.
Crowe et al., Experiments with Normal and Transformed Cells, Cold Spring Harbor, N.Y., 1978, pp. 28, 58-59.
Weinberg, (1981) Biochimica et Biophysica Acta 651: 25-35.
Krontiris et al., (1981) Proceedings of the National Academy of SciencesUSA 78: 1181-1184.
Shih et al., (1981) Nature (London) 290: 261-264.
Perucho et al., (1981), Cell 27: 467-476.
Littlefield (1982) Science 218: 215-216.
Smith et al., (1982) Proceedings of the National Academy of Sciences USA 79: 1964-1968.
Pellicer et al., (1980) Science 209: 1414-1422.
Cline et al., (1980) Nature (London) 284: 422-425.
Mercola et al., (1980) Science 208: 1033-1035.
Anderson et al., (1980) Proceedings of the National Academy of Sciences USA 77: 5399-5403.
Anderson et al., (1981) Scientific American 245: 106-121.
Jonak and Kennett, "Transfection of Primary Mouse Lymphocytes with Human Tumor DNA: Production of Continuous Cell Lines Producing Monoclonal Antibodies", Second Annual Congress for Hybridoma Research, Abstract, (Feb. 6-10, 1983).
Jonak and Kennett, (1983) Hybridoma 2: 124 (reprint of above abstract).
Biotechnology Newswatch, Feb. 21, 1983, pp. 1-2.
Immunology Today, Mar. 1983, p. 2.
Genetic Engineering News, May/Jun. 1983, p. 7.
Science News, Feb. 19, 1983, p. 125.

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