Continuous low-dose administration of parathyroid hormone or its

Details Continuous low-dose administration of parathyroid hormone or its Continuous low-dose administration of parathyroid hormone or its

1996-09-30

1998-05-05

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530324, C07K 1400, A61K 5100, G01N 33534

Patent

active

057474567

ABSTRACT:
A method of promoting bone formation in a human patient, which includes the step of administering continuously to the patient parathyroid hormone or its agonist for a period of at least one month at a dosage between 10 and 400 units/24 hrs. Also disclosed are novel parathyroid hormone agonists.

REFERENCES:
patent: 4656250 (1987-04-01), Morita et al.
patent: 4771124 (1988-09-01), Rosenblatt et al.
Dempster et al. Endocrinse Reviews, vol. 14(6), pp. 690-709, (1993).
Dempster et al., "Anabolic Actions of Parathyroid Hormone on Bone", Endocrine Reviews 14:690-709, 1993.
Hesch et al., "Increase of Vertebral Density by Combinaiton Therapy with Pulsatile 1-38hPTH and Sequential Addition of Calcitonin Nasal Spray in Osteoporotic Patients", Calcified Tissue Int'l 44:176-180, 1989.
Liu et al., "Human Parathyroid Hormone-(1-34) Prevents Bone Loss and Augments Bone Formation in Sexually Mature Ovariectomized Rats", Journal of Bone and Mineral Research 5:973-982, 1990.
Malluche et al., "Effects of long-term infusion of physiologic doses of 1-34 PTH on bone", The American Physiological Society, F197-F201, 1982.
Podbesek et al., "Effects of two treatment Regimes with Synthetic Human Parathyroid Hormone Fragment on Bone Formation & the Tissue Balance of Trabecular Bon in Greyhounds",Endocrinology 1000-1006, 1983.
Reeve et al., "Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporsis: a multicentre trial," British Medical Journal 1340-1343, 1980.

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