Continuous large-scale production of ethyl 2,2-difluoro-4-penten

Details Continuous large-scale production of ethyl 2,2-difluoro-4-penten Continuous large-scale production of ethyl 2,2-difluoro-4-penten

1988-01-15

1989-07-11

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

422119, 422203, 422205, 422208, 422226, 558452, 560219, C07C12000, C07C12142, C07C 6963, C07C 6965

Patent

active

048474010

ABSTRACT:
The large scale preparation of ethyl 2,2-difluoro-4- pentenoate and 2-fluorinated methyl aminoacetonitriles by reaction of 2-H-perfluoroethyl allyl ether and n-butyl lithium and fluoromethylacetonitrile and a Grignard reagent, respectively, is largly unsuccessful because of side reactions which convert intermediate products and reactants to undesired products. Applicants have overcome these problems by performing the reactions with cooling in a continuous manner in a flow reactor with short residence time.

REFERENCES:
patent: 1835827 (1931-12-01), Varnes
patent: 2667348 (1953-12-01), Bonilla
patent: 3028227 (1962-04-01), Ballestra
patent: 3313838 (1967-04-01), Rozzi
patent: 3622281 (1971-11-01), Milligan et al.
patent: 3635682 (1972-01-01), Vine et al.
patent: 3663179 (1972-05-01), Mehta et al.
patent: 4585622 (1986-04-01), Bowe et al.

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