Continuous intravenous infusion of adenosine to human patients u

Details Continuous intravenous infusion of adenosine to human patients u Continuous intravenous infusion of adenosine to human patients u

1993-12-15

1995-09-12

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 276, A61K 3170

Patent

active

054496659

ABSTRACT:
This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human patients by continuous intravenous infusion for, inter alia, control of blood pressure, use as a selective vasodilator, decreasing pulmonary vascular resistance, treating acute pulmonary hypertension in conjunction with idiopathic respiratory distress syndrome, in diagnosing pulmonary hypertension in conjunction with cardiac septum defects, in percutaneous transluminal angioplasty (PTCA), in coronary thrombolysis (CTL) and in radionucleide scintography.

REFERENCES:
patent: 4673563 (1987-06-01), Berne et al.
patent: 5104859 (1992-04-01), Sollevi
patent: 5231086 (1993-07-01), Sollevi
Fukunaga et al. (I), "Hypotensive Effects of Adenosine and Adenosine Triphosphate Compared with Sodium Nitroprusside", Anesthesia and Analgesia, 61, 273-278 (1982).
Fukunaga et al. (II), "ATP-Induced Hypotensive Anesthesia During Surgery," Anesthesiology, 57(3), A65 (1982).
Masters et al., "Platelet Anti-aggregating and Hemodynamics Effects of Adenosine and Prostaglandin E.sub.1 ", Thorac. Cardiovasc. Surgeon, 30, 14-20 (1982).
Kassel et al., "Cerebral and Systemic Circulatory Effects of Arterial Hypotension Induced by Adenosine," J. Neurosurg. 58, 69-76 (1983).
Sollevi et al., "Relationship Between Arterial and Venous Adenosine Levels and Vasodilation During ATP-and Adenosine-Infusion in Dogs," Acta Physiol. Scand., 120, 171-176 (1984).
Olsson et al., "Coronary Vasodilation of Adenosine in the Conscious Dog," Circulation Research, 45(4), 468-478 (1979).
Drury et al., "The Physiological Activity of Adenine Compounds with Especial Reference to Their Action Upon the Mammalian Heart," J. Physiology (Cambridge), 68, 213-237 (1929).

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