Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1989-10-31
1991-07-16
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514784, 514822, 514 23, 424678, 424679, 424682, 424680, A61K 3119, A61K 4700
Patent
active
050326155
ABSTRACT:
The present invention provides a method of preventing blood from clotting in a filter during continuous arteriovenous or venovenous hemodialysis on a patient comprising administering to the blood an amount of citrate sufficient to prevent clotting in the filter. The invention preferably utilizes a dialysate having a sodium and calcium concentration below that of normal blood and an alkali concentration sufficiently low to reduce or prevent alkalosis.
REFERENCES:
patent: 3962075 (1976-06-01), Fialkoff et al.
patent: 4500309 (1985-02-01), Diederich et al.
Chemical Abstracts (108:226817g) 1988.
Chemical Abstracts (109:27520a) 1988.
Morita et al., Regional Anticoagulation During Hemodialysis Using Citrate, The American Journal of the Medical Sciences, 242:32-43 (1961).
Pinnick et al., Regional Citrate Anticoagulation for Hemodialysis in the Patient at High Risk for Bleeding, The New Encland Journal of Medicine 308:258-261 (1983).
Loh et al., Regional Citrate Anticoagulation for Hemodialysis following Cardiovascular Surgery, Am. J. Nephrol. 8:368-372 (1988).
von Brecht et al., Regional ANtiocoagulation: Hemodialysis with Hypertonic Trisodium Citrate, American J. of Kidney Diseases, 8:196-201 (1986).
Hocken, A. G. and Hurst, P. L., Citrate Regional Anticoagulation in Haemodialysis Nephron 46:7-10 (1987).
Mehta Ravindra L.
Ward David M.
The Regents of the University of California
Waddell Frederick E.
Weddington Kevin E.
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