Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-06-07
1997-09-16
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424423, 424427, 424430, 424435, 424436, 424443, 424451, 424464, 514937, A61K 950, A61K 948, A61F 202, A61F 606
Patent
active
056678096
ABSTRACT:
A method for preparing a pharmaceutical microdispersion exhibiting enhanced bioavailability, including the steps of providing a thermodynamically stable pharmaceutical composition comprising at least one lipophilic pharmaceutical agent incorporated in a physiologically acceptable liquid carrier, the liquid carrier comprising one or more lipophilic solvents such as fluorochemicals and preferably at least one nonfluorinated co-solvent, and combining the stable pharmaceutical composition with an amount of at least one miscible diluent sufficient to initiate phase separation of the lipophilic pharmaceutical agent from the pharmaceutical composition wherein a microdispersion of the pharmaceutical composition is formed. Also disclosed are microdisperse pharmaceutical compositions and kits for forming such compositions.
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Dellamary Luis A.
Ranney Helen M.
Tarara Thomas E.
Trevino Leo A.
Weers Jeffry G.
Alliance Pharmaceutical Corp.
Azpuru Carlos A.
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