Continuous flow peptide synthesizer

Details Continuous flow peptide synthesizer Continuous flow peptide synthesizer

1987-01-21

1989-08-29

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530334, 422134, 422188, 525 5411, C12M 100, C12M 136, A61K 3702, C07C10352

Patent

active

048618667

ABSTRACT:
A continuous flow peptide synthesizer (10) has reservoirs (12-42) for amino acid derivatives and reservoirs (154-156 and 161-167) for peptide synthesis reagents and solvents. A column (44) has column segments (224, 226, 228) forming stacked interconnected chambers for holding peptide synthesis polymeric resin supports (260). Each of the amino acid derivative reservoirs (12-42) and the reagent and solvent reservoirs (152-154 and 161-167) are connected through a separate controllable valve (46-76, 154-156 or 182-194) to the column (44). A pressurized source (106) of helium or other inert gas is provided for transferring the amino acid derivatives, reagents and solvents to the column (44). The column segments (224) are also used in a vessel (270) for confining the polymeric resin supports (260) in the vessel during cleavage of the peptides from the supports (260).

REFERENCES:
patent: 4065412 (1977-12-01), Dreyer
patent: 4130514 (1978-10-01), Enkoji et al.
patent: 4192798 (1980-03-01), Verlander et al.
patent: 4362699 (1982-12-01), Verlander et al.
patent: 4517338 (1985-05-01), Urdea et al.
patent: 4598049 (1986-07-01), Zelinka et al.

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