Chemistry: analytical and immunological testing – Including sample preparation – Volumetric liquid transfer
Patent
1982-11-15
1985-05-14
Richman, Barry S.
Chemistry: analytical and immunological testing
Including sample preparation
Volumetric liquid transfer
7386422, 422 82, 422100, 436 53, G01N 114, G01N 3508
Patent
active
045173028
ABSTRACT:
Continuous flow metering apparatus and methods using liquid position sensors in conjunction with flow-stopping valves control (meter) fluid, e.g. sample/reagent/air, aspiration into a single conduit, such as in a continuous flow system. Air or other gas separates selected ones of the liquid segments. The volume of the aspirated segment is established by sensing a flow parameter of the segmented stream of a selected one of the sensors. A pulse is generated by the sensors (detectors), for example due to the change of light intensity at a liquidair interface traversing the conduit. The signal pulse from a sensor causes the actuation of a selected one of the valves and stops aspiration (flow) of the liquid by traversing the flow path in the conduit through an air segment. The valve cuts through air only. Therefore, the body of the valve does not contact reagent or sample liquid by this action and the risk of carryover contamination is avoided. With the aspiration cycle completed, the input end of the conduit, e.g. an aspirating probe, can consequently be immersed in different media and the cycle repeated.
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Gzybowski Michael S.
Richman Barry S.
Technicon Instruments Corporation
Tedesco S. P.
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