Continuous fermentation process for aromatic hydrocarbon bioconv

Details Continuous fermentation process for aromatic hydrocarbon bioconv Continuous fermentation process for aromatic hydrocarbon bioconv

1984-07-27

1990-11-06

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435136, 435143, 435813, 435877, 4352533, 435875, 435876, C12P 744

Patent

active

049686127

ABSTRACT:
This invention provides a continuous bioconversion process in which a non-growth toluene substrate is bio-oxidized by a specific microbe mutant strain to accumulated extracellular muconic acid at a bioreactor production rate of at least about 5 grams of muconic acid per liter of fermentation medium per hour.
Essential features of the invention process include a continuous feed of whole cell-containing fermentation broth from an auxiliary cell growth and enzyme induction fermentation zone into the main fermentation zone, and a purge stream of whole cell-containing fermentation broth from the main fermentation zone.

REFERENCES:
patent: 4480034 (1984-10-01), Hsieh
Atkinson et al. (1983), pp. 608-613, "Biochemical Engineering & Biotechnology Handbook", The Nature Press.
Kirk-Othmer Encyclopedia of Chemical Technology (1980), 3rd Ed., pp. 874-880.

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