Continuous delivery of luteinizing hormone releasing hormone com

Details Continuous delivery of luteinizing hormone releasing hormone com Continuous delivery of luteinizing hormone releasing hormone com

1986-03-21

1988-08-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424430, 424432, 424434, 424433, 424436, 424464, 514 15, 514800, 514843, A61F 200

Patent

active

047627174

ABSTRACT:
This invention is directed to a delivery system and a method useful for preventing pregnancy in female mammals by administering an LHRH composition. The method comprises administering during the entire follicular phase of the menstrual cycle, beginning at the time of menses, an LHRH composition and sufficient levels of an estrogenic steroid to counteract the possibility of side effects which may develop during prolonged therepy with LHRH. Following the follicular phase, at the beginning of the luteal phase, and for the entire course of the luteal phase, the LHRH/estrogenic steroid combination administered during the follicular phase, in combination with a physiological amount of progestational steroid, is administered.
The delivery system comprises means for administering the LHRH composition, estrogenic steroid and progestational steroid.

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