Continuous delivery of luteinizing hormone releasing hormone com

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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424 45, 424423, 424433, 424434, 424435, 424437, 424464, 424DIG14, 424DIG15, 514874, 514899, A61K 902, A61K 910, A61K 920, A61K 3732

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active

051301377

ABSTRACT:
This invention is directed to a delivery system and a method useful for the treatment of benign ovarian secretory disorders in female mammals by administering an LHRH composition. The method comprises administering during the entire follicular phase of the menstrual cycle, beginning at the time of menses, an LHRH composition and sufficient levels of an estrogenic steriod to counteract the possibility of side effects which may develop during prolonged therapy with LHRH. Following the follicular phase, at the beginning of the luteal phase, and for the entire course of the luteal phase, the LHRH/estrogenic steroid combination administered during the follicular phase, in combination with a physiological amount of progestational steroid, is administered.

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Chang, R. J. et al., J. Clin. Endocrin. Metab., 56:897-903 (1983).
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Comite, F. et al., N. Eng. J. Med., 305:1546-1550 (1981).
McLachlan, R. I. et al., Brit. J. Obstet. Gynaecol., 93:431-454 (1986).
Saumande, J. et al., Theriogenology, 12:27-31 (1979).

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