Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2003-10-20
2009-06-09
Vanore, David A. (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S281000
Reexamination Certificate
active
07544932
ABSTRACT:
Contiguous capillaries useful for separating and electrospraying a fluid comprising analyte and electrolyte are provided. The contiguous capillaries have spray tips at one end of the capillaries and electrically conductive portions in proximity to the spray tips. Methods for making the contiguous capillaries and their use as electrospray sources are also disclosed. Apparatus and methods for conveying analyte ions from the capillaries into analytical instruments, such as a mass spectrometer, are also disclosed. The disclosed contiguous capillaries may be used to carryout electrophoresis separation and electrospray ionization of analytes. Methods for obtaining the mass spectra of macromolecular analytes at concentrations lower than previously possibly are provided using the apparatus and procedures described herein.
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Conrads Thomas P
Issaq Haleem J
Janini George
Veenstra Timothy D
Wilkens Kenneth L
Smyth Andrew
The United States of America, as represented by the Secretary, o
Vanore David A.
Woodcock & Washburn LLP
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