Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1994-04-12
1996-04-09
Kestler, Kimberly J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514178, 552553, 540114, A61K 3158, C07J 900
Patent
active
055062210
ABSTRACT:
The invention presents compounds useful for the prevention of inflammatory or allergic reaction or the treatment of cardiovascular or haemodynamic disorders having the formula: ##STR1## where R= ##STR2## where R= ##STR3## or pharmaceutically acceptable acids or salts thereof.
REFERENCES:
patent: 5079239 (1992-01-01), Sun et al.
"Contignasterol, a Highly Oxygenated Steroid with the `Unnatural` 148 configuration from the Marine Sponge Petrosia contignata thiele, 1899", David L. Burgoyne et al., J. Org. Chem. 1992, 57, 525-528.
Bramley et al., "Pharmacological Activity of Pneumocort: A Novel Naturally Occurring Steroid Anti-Asthma Therapy, Isolated From A Marine Sponge," IBC Conference on Allergic Diseases and Asthma-New Approaches for Treatment, Washington D.C., 1993.
Bramley et al., "Effect of a Novel Steroid Pneumocort on Ovalbumin Induced Hyperresponsiveness in Guinea Pigs" American Journal of Respiratory and Critical Care Medicine 149(4): abstract A768, 1994.
Shoji et al., "Two Unique Pentacyclic Steroids with Cis C/D Ring Junction from Xestospongia bergquistia Fromont, Powerful Inhibitors of Histamine Release," Journal of Organic Chemistry 57:2996-2997, 1992.
Allen Theresa M.
Andersen Raymond J.
Burgoyne David L.
Kestler Kimberly J.
University of Alberta
University of British Columbia
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